Results 141 to 150 of about 1,556 (213)

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1419-1427, September 2026.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, Volume 4, Issue 3, September 2026.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Spatial and Temporal Heterogeneity of Macrophage Efferocytosis in Tumors: Emerging Implications for Immunotherapy Biomarkers and Therapeutic Timing

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Resistance to immune checkpoint blockade (ICB) remains a major barrier in cancer therapy, reflecting the fact that tumor immunity is governed not only by cell type abundance but also by spatial organization and temporal dynamics within the tumor microenvironment (TME).
Shanyi Li, Jilei Li, Zhenyu Zhang, Sizhe Wang, Chunzheng Ma   +4 more
wiley   +1 more source

Efficacy and Safety of Neoadjuvant Chemotherapy Followed by CDK4/6 Inhibitors Plus Endocrine Therapy in Patients With HR‐Positive, HER2‐Negative Breast Cancer: A Retrospective Single‐Centre Cohort Analysis

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Endocrine therapy with CDK4/6 inhibitor has been the main treatment for HR+/HER2− breast cancer in the adjuvant setting; however, the data on the application in the neoadjuvant setting is limited. We compared neoadjuvant efficacy and safety of sequential chemotherapy‐CDK4/6 inhibitors with chemotherapy alone in HR+/HER2− breast ...
Xiaopei Dong, Fan Li, Yang Yuan, Hua Song, Yingzhe Wang, Yi Hao, Yinping Dong, Tao Wang, Li Bian, Shaohua Zhang, Jianbin Li   +10 more
wiley   +1 more source

Age‐Associated Four‐Gene Prognostic Signature in Breast Cancer

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Young‐onset breast cancer is associated with inferior disease‐free survival (DFS), but the contribution of additional molecular heterogeneity remains unclear. Aims To identify an exploratory age‐associated gene expression signature linked to recurrence‐related outcomes and evaluate its prognostic association.
Shiro Uchida
wiley   +1 more source

Durable Intracranial Response to Sacituzumab Tirumotecan in HER2‐Negative Salivary Duct Carcinoma With High TROP2 Expression: A Case Report

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Salivary duct carcinoma is an aggressive salivary gland malignancy in which systemic therapy is often guided by androgen receptor and HER2 status. Treatment options are limited for HER2‐negative disease after progression on androgen‐deprivation therapy and chemotherapy, particularly when active central nervous system (CNS ...
Guang‐Liang Chen, Biao Tan, Sufen Cao, Xin Liu, Yanjing Guo, Dongmei Ji   +5 more
wiley   +1 more source

Age at First Pregnancy, Adult Weight Gain and Postmenopausal Breast Cancer Risk: The PROCAS Study (United Kingdom)

International Journal of Cancer, Volume 159, Issue 5, Page 1228-1239, 1 September 2026.
An early first pregnancy is protective against postmenopausal breast cancer. However, pregnancy is also a key contributor to weight gain, and adult weight gain increases postmenopausal breast cancer risk. This prospective cohort study quantified the combined effect of adult weight gain and age at first pregnancy on postmenopausal breast cancer risk ...
Lee Malcomson, Adam Brentnall, Andrew G. Renehan, Mary Pegington, Elaine F. Harkness, Jake Southworth, D. Gareth Evans, Michelle Harvie   +7 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This comprehensive review highlights the transformative role of 3D printing and bioprinting technologies in the regeneration of female reproductive organs and the treatment of gynecological diseases. Unlike previous overviews that focus narrowly on isolated applications, this work provides an integrative analysis of recent clinical and preclinical ...
Chan Hum Park, In‐Sun Hong
wiley   +1 more source