Results 111 to 120 of about 24,787 (310)
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis [PDF]
, 2015 Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of ...(AAGC), Australian Asthma Genetics Consortium, Altmaier, Elisabeth, Alves, Alexessander Couto, Arnold, Andreas, Bacelis, Jonas, Barton, Sheila J, Bataille, Veronique, Bauerfeind, Anja, Baurecht, Hansjörg, Bisgaard, Hans, Boomsma, Dorret I, Brown, Sara J, Bunyavanich, Supinda, Burchard, Esteban G, Bustamante, Mariona, Bønnelykke, Klaus, Campbell, Linda E, Carstensen, Lisbeth, Cichon, Sven, Consortium, Lifecourse Epidemiology (EAGLE) Eczema, Curjuric, Ivan, Curtin, John A, Custovic, Adnan, de Jongste, Johan C, den Dekker, Herman T, Duijts, Liesbeth, Elbert, Niels J, Eng, Celeste, Esparza-Gordillo, Jorge, Evans, David M, Fahy, Caoimhe M R, Feenstra, Bjarke, Ferreira, Manuel A, Franke, Andre, Fölster-Holst, Regina, Geller, Frank, Genetics, EArly, Gieger, Christian, Glass, Daniel, Godfrey, Keith M, Gonzalez, Juan R, Grarup, Niels, Groen-Blokhuis, Maria M, Hakonarson, Hakon, Heinrich, Joachim, Henderson, A John, Hinds, David A, Hirota, Tomomitsu, Hofman, Albert, Holloway, John W, Homuth, Georg, Horikoshi, Momoko, Hottenga, Jouke Jan, Hotze, Melanie, Hu, Donglei, Huntsman, Scott, Husemoen, Lise L, Hysi, Pirro, Hübner, Norbert, Imboden, Medea, Irvine, Alan D, Jacobsson, Bo, Jaddoe, Vincent W V, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Kalb, Birgit, Keil, Thomas, Kemp, John P, Koppelman, Gerard H, Kreiner-Møller, Eskil, Kubo, Michiaki, Kumar, Ashish, Kurek, Michael, Lau, Susanne, Lee, Young-Ae, Lee-Kirsch, Min Ae, Levin, Albert M, Li, Jin, Lieb, Wolfgang, Linneberg, Allan, Lockett, Gabrielle A, Macek, Milan, Mangold, Elisabeth, Marenholz, Ingo, Marks, Guy B, Martin, Nicholas G, Matanovic, Anja, Matheson, Melanie C, McAleer, Maeve A, McArdle, Wendy L, McLean, W H Irwin, Melbye, Mads, Melén, Erik, Meyers, Deborah A, Middeldorp, Christel M, Myers, Rachel A, Myhre, Ronny, Novak, Natalija, Nystad, Wenche, Nöthen, Markus M, O'Regan, Grainne M, Ober, Carole, Pahukasahasram, Badri, Pasmans, Suzanne G M A, Paternoster, Lavinia, Pekkanen, Juha, Pennell, Craig E, Peters, Annette, Pino-Yanes, Maria, Postma, Dirkje S, Probst-Hensch, Nicole M, Raby, Benjamin A, Relton, Caroline L, Ried, Janina S, Rivadeneira, Fernando, Robertson, Colin F, Rodríguez, Elke, Rüschendorf, Franz, Schmidt, Carsten O, Sebert, Sylvain, Simpson, Angela, Sleiman, Patrick M A, Smith, George Davey, Spector, Tim, Standl, Marie, Strachan, David P, Sun, Liang Dan, Sunyer, Jordi, Söderhäll, Cilla, Takahashi, Atsushi, Tamari, Mayumi, Thiering, Elisabeth, Thompson, Philip J, Thyssen, Jacob P, Tian, Chao, Tiesler, Carla M T, Tung, Joyce Y, Uitterlinden, André G, Venturini, Cristina, Vilor-Tejedor, Natàlia, Waage, Johannes, Wang, Carol A, Weidinger, Stephan, Weiss, Scott T, Williams, L Keoki, Xiao, Feng Li, Xu, Cheng-Jian, Yang, James J, Yin, Xian Yong, Zhang, Xue Jun, Zheng, Jie, Zheng, Xiao Dong, Zuo, Xian Bo +152 morecore +6 more sourcesA Delphi Consensus on Clinical Features, Diagnosis, and Treatment of Chronic Rhinosinusitis With Nasal Polyps in the ASEAN Region
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background
Chronic rhinosinusitis with nasal polyps (CRSwNP) impacts patients' concentration, ability to work, and overall quality of life. Current treatment options include topical and oral medications, and surgery. Recent evidence supports the efficacy of biologics in improving symptoms and quality of life.Baharudin Abdullah, Revadi Govindaraju, Salina Husain, Jin Keat Siow, Pongsakorn Tantilipikorn, Neville Wei Yang Teo, De Yun Wang, Deasi Anggraini, Tze Choong Charn, Chao‐Wu David Chin, Dichapong Kanjanawasee, Maung Maung Khaing, Jern‐Lin Leong, Luan Viet Tran, Harvinder Singh, Ing Ping Tang, Kim Thye Mark Thong, Gil M. Vicente, Yoke Yeow Yap, Soma Subramaniam +19 morewiley +1 more sourceMepolizumab versus placebo for asthma [PDF]
, 2015 Background Mepolizumab is a human monoclonal antibody against interleukin-5 (IL-5), the main cytokine involved in the activation of eosinophils, which in turn causes airway inflammation.Alvarez-Cuesta, Armentia, Ayars, Ayars, Ayres, Bel, Berger, Blanken, Blanken, Boever, Boulet, Bousquet, Bousquet, Braman, Brown, Bryant, Bryant, Buhl, Buhl, Buhl, Bush, Busse, Busse, Buttner, Caffarelli, Castro, Castro, Chandra, Chervinsky, Clavel, Corren, Corren, Cruz, Cullell-Young, Djukanovic, Ebner, Eckman, El-Nawawy, Fahy, Fahy, Finn, Flood-Page, Flood-Page, Flood-Page, Flood-Page, Frew, Fuhlbrigge, Garcia, Gauvreau, Gauvreau, Gauvreau, Gauvreau, Gevaert, Gibson, Gordon, Greenberg, Gupta, Haldar, Haldar, Haldar, Han, Hanania, Hanania, Hanania, Hill, Hodsman, Holgate, Hoshino, Humbert, Humbert, Humbert, Jacquemin, Jutel, Kandane-Rathnayake, Kang, Kay, Kips, Kon, Kopp, Kopp, Krishnan, Kulus, Lanier, Lanier, Laviolette, Leckie, Leynadier, Lizaso, Masoli, Massanari, Massanari, Mathur, Menzies-Gow, Menzies-Gow, Metzger, Milgrom, Milgrom, Modlin, Moss, Nair, Nair, Nair, Niven, Noga, Noga, Noonan, Oba, Oh, Ohashi, Ohman, Ohta, Ong, Ortega, Ortega, Parker, Patel, Pauli, Pavord, Pavord, Phipps, Piper, Prieto, Pui, Rensen, Rose, Sakamoto, Scheerens, Scheerens, Siergiejko, Silk, Silkoff, Simoes, Singh, Slavin, Soler, Sorkness, Sthoeger, Sugaya, Swanson, Szymaniak, Tanaka, Terr, Vignola, Wark, Wenzel, Wenzel, Wu, Zetterstrom, Zhu, Zielen +149 morecore +2 more sourcesObesity and Its Impact on Endoscopic Sinus Surgery Outcomes in Patients With Chronic Rhinosinusitis With Nasal Polyps
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Purpose
The rising prevalence of obesity introduces challenges in surgical contexts, including endoscopic sinus surgery (ESS) for chronic rhinosinusitis with nasal polyps (CRSwNP). However, the impact of obesity on ESS outcomes remains underexplored. This study aims to evaluate the association between obesity and surgical complexity, operative Hen Chaushu, Narin Nard Carmel Neiderman, Yuval Presman, Alexandra Dorman, Roni Vass, Nidal Muhanna, Avraham Abergel +6 morewiley +1 more sourceThe Utility of Intranasal Corticosteroids in Association With Dupilumab for Chronic Rhinosinusitis With Nasal Polyposis: A Real‐Life Multicenter Study by a Tuscany Group
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition often associated with other type‐2 diseases. Dupilumab, a monoclonal antibody targeting IL‐4Rα, has revolutionized the treatment of severe CRSwNP.Pietro Orlando, Giuseppe Licci, Marella Reale, Veronica Seccia, Alessia Giorli, Paolo Iannicelli, Dario Zaccari, Valentina Rossi, Jacopo Cambi, Stefano Berrettini, Marco Mandalà, Gianluca Leopardi, Antonio Sarno, Luca Muscatello, Simone Bocuzzi, Franco Trabalzini, Giandomenico Maggiore, Oreste Gallo +17 morewiley +1 more sourceDupilumab-Associated Blepharoconjunctivitis with Giant Papillae
International Medical Case Reports Journal, 2020 Filippos Vingopoulos, Douglas R Lazzaro New York University School of Medicine, Department of Ophthalmology, New York, NY 10017, USACorrespondence: Douglas R LazzaroNew York University School of Medicine, Department of Ophthalmology, 222 East 41st Street,Vingopoulos F, Lazzaro DRdoaj Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme [PDF]
, 2015 BACKGROUND : The most prevalent phenotype of asthma is characterized by eosinophil-dominated inflammation that is driven by a type 2 helper T cell (Th2).Bachert, Claus, Beeh, Kai M, Bille, Joachim, Buhl, Roland, Garn, Holger, Hohlfeld, Jens M, Homburg, Ursula, Ignatenko, Stanislav, Kappeler, Dominik, Kirsten, Anne-Marie, Korn, Stephanie, Kornmann, Oliver, Krug, Norbert, Renz, Harald, Renz, Jonas, Rogon, Cordelia, Timmer, Wolfgang, Turowska, Agnieszka, Werfel, Thomas, Zeitvogel, Jana, Zhang, Nan +20 morecore +2 more sourcesDupilumab in children with eosinophilic esophagitis: a retrospective multicenter study
BMC PediatricsBackground Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation. Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal +11 moredoaj +1 more source
