Results 101 to 110 of about 16,542 (247)

Epiphora: A Structured Diagnostic Approach for the Otolaryngologist

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Epiphora, or excessive tearing, has historically been predominantly managed by ophthalmologists. However, as there is substantial overlap between ophthalmic and otolaryngologic anatomy and pathology that may contribute to epiphora, patients with this symptom often present to otolaryngologists as well.
Luke M. O'Neil, Sam Kushner‐Lenhoff, Alexandra Van Brummen, Christopher Chambers, Hector Perez, Ashton E. Lehmann, Matthew M. Zhang, Aria Jafari   +7 more
wiley   +1 more source

Dupilumab Reduces Urticaria Activity, Itch, and Hives in Patients with Chronic Spontaneous Urticaria Regardless of Baseline Serum Immunoglobulin E Levels

Dermatology and Therapy
Introduction In chronic spontaneous urticaria (CSU), interleukin (IL)-4 and IL-13 may promote mast cell activation directly via IL-4 receptor expression, or indirectly via upregulated immunoglobulin E (IgE) production.
Marcus Maurer, Thomas B. Casale, Sarbjit S. Saini, Moshe Ben-Shoshan, Elizabeth Laws, Jennifer Maloney, Deborah Bauer, Allen Radin, Melanie Makhija   +8 more
doaj   +1 more source

Dupilumab-Associated Blepharoconjunctivitis with Giant Papillae

International Medical Case Reports Journal, 2020
Filippos Vingopoulos, Douglas R Lazzaro New York University School of Medicine, Department of Ophthalmology, New York, NY 10017, USACorrespondence: Douglas R LazzaroNew York University School of Medicine, Department of Ophthalmology, 222 East 41st Street,
Vingopoulos F, Lazzaro DR
doaj  

Eosinophilic Sialodochitis Identified in Duct Remnant After Submandibular Gland Resection

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Eosinophilic sialodochitis (ES) is an increasingly recognized cause of recurrent sialadenitis but likely remains underdiagnosed as it is commonly considered to be nonspecific chronic sialadenitis. ES is likely increasing in prevalence in association with the growing number of allergic diseases and should be considered in patients presenting ...
Edward Tannenbaum, Claire Orth, Nicole Becker, Henry Hoffman   +3 more
wiley   +1 more source

Dupilumab induces long-term on-treatment clinical remission in patients with type 2 asthma

Background Remission is proposed as a multicomponent outcome for patients with severe asthma. Objective This post hoc analysis of QUEST (NCT02414854) and TRAVERSE (NCT02134028) evaluated whether dupilumab treatment leads to clinical asthma remission (≥12
Pavord, Ian D., Altincatal, Arman, Szefler, Stanley J., Israel, Elliot, Zhang, Yi, Deniz, Yamo, Radwan, Amr, Lederer, David J., Khan, Asif H., Rabe, Klaus F., Pandit-Abid, Nami, Busse, William W., Amin, Nikhil, Brusselle, Guy, Chen, Zhen, Jacob-Nara, Juby A., Rowe, Paul J.   +16 more
core   +1 more source

Impact of Dupilumab Therapy on Skin Barrier Function in Patients With Moderate-to-Severe Atopic Dermatitis: A Phase IV, Non-Randomized, Open-Label, Parallel-Group Clinical Study. [PDF]

MedComm (2020)
This 16‑week study assessed impact of dupilumab on skin barrier function in patients with moderate‑to‑severe atopic dermatitis (AD). Tape‑stripped stratum corneum samples for multi‑omic profiling, alongside transepidermal water loss measurements, were collected from lesional/non‑lesional AD skin and healthy controls at seven time points.
Liu T, Chen S, Zhao W, Di D, Liu J, Tian Y, Luo Y, Xu Y, Xue R, Ye L, Pei X, Yu B, Wang Y, Zhang J, Yu X, Wen W, Yuan L, Ji S, Hu C, Shen D, Guo Y, Liang Y.   +21 more
europepmc   +2 more sources

Treatment Persistence and Factors Associated With Discontinuation in Real‐World Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Background Biologic therapies are effective for severe, uncontrolled CRSwNP, yet real‐world data on treatment persistence remain limited. Methods This retrospective single‐center study included 95 adults with CRSwNP who initiated dupilumab (88.4%), mepolizumab, or omalizumab between 2021 and 2025.
Chaushu H, Presman Y, Vass R, Carmel‐Neiderman N, Kampel L, Jahashan F, Muhanna N, Bandora E, Abergel A.   +8 more
europepmc   +2 more sources

Screening olfaction under dupilumab in chronic rhinosinusitis with nasal polyps.

BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently leads to olfactory dysfunction. This study aimed to assess the impact of dupilumab on CRSwNP patients, focusing on olfactory outcomes and potential correlations with other ...
Steiner, U C, Brühlmann, C, Yalamanoglu, A, Ryser, F S, Meerwein, C M, Mauthe, T, Soyka, M B, Steiner, Urs Christian, Ryser, Fabio Simon, Meerwein, Christian M; https://orcid.org/, Steiner, Urs C; https://orcid.org/, Yalamanoglu, Ayla; https://orcid.org/, Soyka, Michael B; https://orcid.org/, Mauthe, Tina   +13 more
core   +1 more source

Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series

Australasian Journal of Dermatology, EarlyView.
ABSTRACT We present three patients who developed allergic contact dermatitis (ACD) from benzalkonium chloride (BAK) in ophthalmic drops. BAK is a preservative commonly found in ophthalmic formulations and there is a rising trend of ACD to this allergen. The irritant and sensitising properties of BAK on the ocular mucosa will be discussed.
Arav Kannen, Penelope Harrison, Elizabeth Christou   +2 more
wiley   +1 more source

Outcomes of Systemic Janus Kinase Inhibitors Following Dupilumab for Dupilumab-Associated Facial and Neck Erythema: A Systematic Review

Dupilumab, an anti-IL-13 and anti-IL-4 antibody, is a mainstay of treatment for moderate-to-severe atopic dermatitis. However, dupilumab-associated facial and/or neck erythema (DA-FNE) has been reported to be a relatively common adverse event. There have
Simpson, Rachel
core   +1 more source