Results 191 to 200 of about 14,376 (241)

Acute ketone monoester ingestion lowers resting cerebral blood flow: a randomized cross‐over trial

The Journal of Physiology, EarlyView.
Abstract figure legend This double‐blind, placebo‐controlled, randomized cross‐over trial investigated the effects of ketone monoester (KME) ingestion on resting cerebral blood flow (CBF) in young adults. We demonstrate that KME supplementation lowers CBF in a dose‐dependent manner over 2‐houra post‐ingestion, whereas CBF remained unchanged following ...
Aedan J. Rourke, Claudia M.S. Yong, Geoff B. Coombs, Addriana R. Odisho, Jenna A. Nash, Jack Bone, Baraa K. Al‐Khazraji, Jeremy J. Walsh   +7 more
wiley   +1 more source

Template-Directed Synthesis of Recognition-Encoded Melamine Oligomers Using a Base-Filling Strategy. [PDF]

J Am Chem Soc
Smith JT, Baixeras Buye J, Iddon B, Soloviev DO, Hunter CA.   +4 more
europepmc   +1 more source

Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study

The Journal of Physiology, EarlyView.
Abstract figure legend Longitudinal assessment of sex differences in cerebrovascular ageing over a ∼6 year period: the Brain in Motion study. Cerebrovascular function was assessed at baseline (T1) and at a follow‐up (T2) ∼6 years later, at rest, during euoxic hypercapnia and while engaging in submaximal exercise. Over the follow‐up period females had a
Connor Snow, Alison M. H. Donald, Kian M. Pelechaty, Jordan Gibson, Michael D. Hill, Jean M. Rawling, Jayna Holroyd‐Leduc, Kara Nerenberg, Jessalyn K. Holodinsky, R. Stewart Longman, Marc J. Poulin   +10 more
wiley   +1 more source

Hydrophobic alkyl-linked base-modified pyrimidine and 7-deazapurine 2'-deoxyribonucleoside phosphoramidites: synthesis and application in solid-phase synthesis of modified and hypermodified oligonucleotides. [PDF]

RSC Adv
Jestřábová I, Bednárová L, Poštová Slavětínská L, Hocek M.   +3 more
europepmc   +1 more source

Two Highly Efficient Prime Editing Systems Based on the Csy4 CRISPR Endonuclease

Plant Biotechnology Journal, EarlyView.
Yu Lu, Dexin Qiao, Junya Wang, Wei Sun, Zhenghong Cao, Minhui Lu, Yiping Chai, Yuanyuan Jiang, Cuiping Xin, Xiaohan Liu, Siyun Li, Syeda Leeda Gul, Qi‐Jun Chen   +12 more
wiley   +1 more source

Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated how 6 weeks of dynamic knee‐extensor interval training with blood flow restriction (BFR‐leg) and without (CTRL‐leg) impacts performance and its mechanisms using non‐invasive methods. Specifically, we used gold‐standard methods to assess neuromuscular function, vascular function using Doppler ultrasound, and near ...
Colin Lavigne, Valentin Mons, Clément Lemineur, Oliver Meste, Georges Lefthériotis, Grégory M. Blain   +5 more
wiley   +1 more source

Hybridization Probes Featuring a Pyrenylpyridine C-Nucleoside or Its Palladacycle as a Fluorescent Sensor Moiety. [PDF]

Chembiochem
Ukale DU, Lönnberg T.
europepmc   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

1,3-Dideazaguanosine in Atomic Mutagenesis Provides Unprecedented Insight Into Hydrogen Bonding and Stacking Interactions in Folded RNA. [PDF]

JACS Au
Oberlechner M, Micura R.
europepmc   +1 more source

A Novel Cell‐Penetrating Lipopeptide for DNA Binding, Self‐Assembly, and Delivery Into HeLa and Pluripotent Stem Cells

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
A lipopeptide is designed that contains an epitope from simian virus T‐antigen (SV40T, PKKKRKV) conjugated to an N‐terminal palmitoyl (C16‐) moiety, which acts as a cell‐penetrating lipopeptide, with additional aggregation propensity conferred by the lipid chain. The lipopeptide enables DNA delivery into the cytoplasm and nucleus.
Lucas R. de Mello, Tâmisa Seeko Bandeira Honda, Valeria Castelletto, Patrícia Terra Alves, Sang Won Han, Emerson Rodrigo da Silva, Ian W. Hamley   +6 more
wiley   +1 more source