Results 211 to 220 of about 121,764 (280)

SOD2‐Superoxide Metabolic Axis Regulates Mitophagy and Modulates TKIs Sensitivity in Head and Neck Squamous Cell Carcinoma

Cancer Science, EarlyView.
Our findings provide compelling evidence that the SOD2‐superoxide metabolic axis functions as a mitochondrial redox checkpoint that governs mitophagy and ultimately shapes TKI sensitivity. ABSTRACT Superoxide dismutase 2 (SOD2) has been implicated in head and neck squamous cell carcinoma (HNSCC), yet its mechanistic contribution in regulating tumor ...
Wan‐Hang Zhou, Shuo‐Jin Huang, An‐Xun Wang   +2 more
wiley   +1 more source

Minor groove tetrads: a potent and versatile capping interaction for i-motif structures. [PDF]

Biophys Rev
Garavís M, Mir B, Serrano-Chacón I, Cabrero C, Ugedo C, Gómez-Pinto I, Escaja N, González C.   +7 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Deep convolutional and fully-connected DNA neural networks. [PDF]

Nat Commun
Liu X, Zheng Z, Liu P, Yang Z, Hu H, Wu M, Lou X, Xia F, Tao K, Li L, Dai J, Xiao X.   +11 more
europepmc   +1 more source

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

The FEBS Journal, EarlyView.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto, Yudai Yamaoki, Takashi Nagata, Masato Katahira   +3 more
wiley   +1 more source

Crystallographic Study of DNA T-Junction via Crystal Engineering. [PDF]

Angew Chem Int Ed Engl
Li X, Siraj N, Sha R, Mao C.
europepmc   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

Duplex Recombinase-Aided Amplification-Lateral Flow Dipstick (dRAA-LFD) Assay for New Zealand Green-Lipped Mussel Authentication. [PDF]

Biosensors (Basel)
Saetang J, Saengthong M, Benjakul S, Moorthy G.   +3 more
europepmc   +1 more source

Unity or Distinction? Herman Bavinck’s Use of John Calvin and Later Reformed Orthodoxy in His Doctrine of the Two States

International Journal of Systematic Theology, EarlyView.
Abstract This article examines the doctrine of Christ’s two states of humiliation and exaltation in Herman Bavinck’s and John Calvin’s thought, with the aim of illuminating Bavinck’s use of Calvin. The article begins by exploring Calvin’s use of the two states and argues that his treatment of Christ’s descent into hell is an important though ...
Sarah Killam Crosby
wiley   +1 more source

Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency. [PDF]

Nucleic Acids Res
Chickering T, Harp JM, Jiang Y, Qin J, He G, Hyde S, Ihlefeld A, Janas M, O'Flaherty DK, Schofield S, Szeto J, Theile CS, Charissé K, Jadhav V, Maier MA, Manoharan M, Egli M, Schlegel MK.   +17 more
europepmc   +1 more source