Results 51 to 60 of about 14,376 (241)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

URLLC-Enabled Full-Duplex Cell-Free Massive MIMO Systems With Mobility

IEEE Open Journal of the Communications Society
In the rapidly evolving domain of intelligent vehicular systems, reliable and instantaneous communication is paramount. This paper delves into the robustness of an ultra-reliable low-latency communication (URLLC)-enabled full-duplex cell-free massive ...
Sravani Kurma, Keshav Singh, Prabhat Kumar Sharma, Chih-Peng Li, Theodoros A. Tsiftsis   +4 more
doaj   +1 more source

Torres Blancas

Festival dell'Architettura Magazine, 2016
Nella Madrid degli anni sessanta l’architetto navarro Sáenz de Oíza sperimenta la costruzione di un edificio residenziale a torre in cemento armato. Risultato della felice relazione con un imprenditore mecenate, Juan Huarte, l’edificio si articola nella ...
José Manuel López-Peláez
doaj   +1 more source

Selective and Precise Editing of Digital Polymers Through Parallel or Series Toehold‐Mediated Strand Displacement

Advanced Functional Materials, EarlyView.
A sequence‐encoded supramolecular construct containing two accessible toeholds is developed herein for enabling multiple editing operations. By introducing specific input strands, it is possible to selectively erase or rewrite digital content through parallel or series toehold‐mediated strand displacement (PTMSD or STMSD).
Jakub Ossowski, Cyril Antheaume, Jean‐François Lutz, Maria Nerantzaki   +3 more
wiley   +1 more source

Synthesis and properties of RNA constrained by a 2’‐O‐disulfide bridge

ChemistryOpen
We recently reported the properties of RNA hairpins constrained by a dimethylene (DME) disulfide (S−S) linker incorporated between two adjacent nucleosides in the loop and showed that this linker locked the hairpin conformation thus disturbing the duplex/
Diallo Traoré, Elisa Biecher, Manon Mallet, Sonia Rouanet, Dr. Jean‐Jacques Vasseur, Prof. Michael Smietana, Dr. Christelle Dupouy   +6 more
doaj   +1 more source

6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

Beilstein Journal of Organic Chemistry, 2018
Here we report on the synthesis, biophysical properties and molecular modeling of oligonucleotides containing unsaturated 6’-fluoro[4.3.0]bicyclo nucleotides (6’F-bc4,3-DNA).
Sibylle Frei, Andrei Istrate, Christian J. Leumann   +2 more
doaj   +1 more source

Experimental study of the mechanical properties of a new duplex stainless steel exposed to elevated temperatures

Case Studies in Construction Materials, 2022
A new duplex stainless steel (S32001) with good corrosion resistance and mechanical properties has been introduced into building structures in recent years.
Shuobiao Li, Wenqi Ding, Qingzhao Zhang, Xiangyong Xiao, Qinglong Zhou   +4 more
doaj   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Tensile Properties and Fracture Analysis of Duplex (2205) and Super Duplex (2507) Stainless Steels, Produced via Laser Powder Bed Fusion Additive Manufacturing

Metals
Additive manufacturing of duplex (DSS) and super duplex stainless steel (SDSS) has been successfully demonstrated using laser powder bed fusion (LPBF) in recent years. Owing to the high cooling rates, as-built LPBF-processed DSS and SDSS exhibit close to
Leonidas Karavias, Leonidas Gargalis, Joachim Seland Graff, Marius Johansen, Spyros Diplas, Evaggelia K. Karaxi   +5 more
doaj   +1 more source