Results 121 to 130 of about 168,322,127 (297)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Incidence and clinical outcomes of extended duration support in patients with Impella 5.5 - Analysis from the LOQI Registry

JHLT Open
Purpose: Impella 5.5 pumps are increasingly used in cardiogenic shock (CS) for extended hemodynamic support (>14 days). Rates of adverse events have not been well-characterized during longer durations of support.
David Kaczorowski, MD, Vidang P. Nguyen, MD, Aasim Afzal, MD, Scott C. Silvestry, MD, Ahmad Zeeshan, MD, Naveena Yanamala, PhD, Ray Matthews, MD, Rothy Chhim, MS, Sanjeev Aggarwal, MD, Sami I. Somo, PhD, Gavin W. Hickey, MD   +10 more
doaj   +1 more source

Supporting the Mind in Space: Psychological Tools for Long-Duration Missions

Interactive Journal of Medical Research
The psychological well-being of astronauts is becoming just as vital as their physical and technical readiness as space missions extend into deep space. Long-duration missions pose unique challenges, such as isolation, confinement, communication delays, and microgravity, which can significantly affect mental health and cognitive performance.
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Identifying excessive length of antibiotic treatment duration for hospital-acquired infections: a semi-automated approach to support antimicrobial stewardship

Antimicrobial Resistance and Infection Control
Background Avoiding excessive antibiotic treatment duration is a fundamental goal in antimicrobial stewardship. Manual collection of data is a time-consuming process, but a semi-automated approach for data extraction has been shown feasible for community-
Suzanne M.E. Kuijpers, Koen J. van Haeringen, Thomas Groot, Kim C.E. Sigaloff, Reinier M. van Hest, Jan M. Prins, Rogier P. Schade   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Impact of the Potential Duration of Unemployment Benefits on the Duration of Unemployment [PDF]

This paper uses two data sets to examine the impact of the potential duration of unemployment insurance (UI) benefits on the duration of unemployment and the time pattern of the escape rate from unemployment in the United States.
Bruce D. Meyer, Lawrence F. Katz
core  

Duration of Breastfeeding and Associated Maternal Factors in Women Attending Baqiyatallah Hospital, Tehran, Iran [PDF]

پژوهان
Background and Objectives: Identifying factors affecting breastfeeding duration can play a key role in designing effective interventions to increase this duration.
Zahra Soleimani, Azam Soleimani, Seyedeh Noushin Ghalandarpoor-Attar, Seyedeh Mojgan Ghalandarpoor-Attar, Mohammad Eamaeilzadeh   +4 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Stability or regularity of the daily travel time in Lyon? Application of a duration model [PDF]

Escaping unidimensional analysis limits and linear regression irrelevancy, the duration model incorporates impacts of covariates on the duration variable and permits to test the dependence of daily travel times on elapsed time.
Iragaël Joly
core