Results 111 to 120 of about 4,362,037 (309)

The importance of word-final vowel duration for non-native portuguese speaker identification by means of Support Vector Machines

Revista Brasileira de Linguística Aplicada, 2014
This article studies the acoustic characteristics of some oral vowels in tonic syllables of Brazilian Portuguese (BP) and which acoustic features are important for classifying native versus non-native speakers of BP.
Suzanne Franks, Rommel Barbosa
doaj  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The role of support on breastfeeding exclusivity and duration among African migrant mothers in the United States

International Breastfeeding Journal
Background The population of African migrant women in the United States (U.S.) is steadily increasing, yet limited research exists on their breastfeeding experiences, support systems, and sources of breastfeeding information.
Tabitha Addy, Laura Nabors, Keith King, Rebecca Vidourek, Danielle Pierre Hixon, Olutosin Sanyaolu   +5 more
doaj   +1 more source

Duration Dependence and Nonparametric Heterogeneity: A Monte Carlo Study [PDF]

We examine the behaviour of the nonparametric maximum likelihood estimator (NPMLE) for a discrete duration model with unobserved heterogeneity and unknown duration dependence.
Angelo Melino, Michael Baker
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

CONGRUENCE OF THE HATCH FUNDED REGIONAL RESEARCH PORTFOLIO WITH NATIONAL AND REGIONAL RESEARCH PRIORITIES [PDF]

The major focus of this report is on evaluation of the extent to which the allocation of regional research funding support, particularly the allocation of Hatch Regional Research Funds (RRF), is congruent with national and regional research priorities ...
Halbach, Daniel Walter, Sundquist, W. Burt   +1 more
core   +1 more source

Enhanced Transmission and Reflection of Femtosecond Pulses by a Single Slit

, 2006
We show that a physical mechanism responsible for the enhanced transmission and reflection of femtosecond pulses by a single subwavelength nanoslit in a thick metallic film is the Fabry-Perot-like resonant excitation of stationary, quasistationary and ...
E. Betzig, F. L. Neerhoff, M. Mechler, O. Samek, S. V. Kukhlevsky   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source