Results 111 to 120 of about 924 (199)

Progress of anti-tuberculosis drug targets and novel therapeutic strategies [PDF]

Tuberculosis, a chronic infectious disease caused by Mycobacterium tuberculosis complex, has re-emerged as the leading cause of death worldwide as a single infectious agent.
Jiayin Xing, Mingrui Sun, Ningning Song, Ren Fang, Ruiying Wu, Xiaotian Li, Yang Zhang, Yurong Wen, Zhaoli Li   +8 more
core   +1 more source

Friends or foes? Novel antimicrobials tackling MDR/XDR Gram-negative bacteria: a systematic review

Frontiers in Microbiology
Gram-negative bacteria have been one of the most studied classes in the field of microbiology, especially in the context of globally alarming antimicrobial resistance levels to these pathogens over the course of the past decades.
Mihai Octavian Dan, Daniela Tǎlǎpan, Daniela Tǎlǎpan   +2 more
doaj   +1 more source

Cefepime-Enmetazobactam: a novel β-Lactam/β-Lactamase inhibitor combination for complicated urinary tract infections [PDF]

Complicated urinary tract infections (cUTIs) represent a significant global health challenge, particularly with the rising prevalence of extended-spectrum β-lactamase (ESBL)-producing pathogens.
Balaji, Vikram, James, Jerin, Nivasini, Natarajan Thangam, Ramaraj, Arunkumar, Varadarajan, Sathyanarayanan   +4 more
core   +2 more sources

Nephrotoxicity of New Antibiotics: A Systematic Review

Toxics
Drug-induced nephrotoxicity is a common and serious problem in clinical practice. We conducted a systematic review of studies reporting nephrotoxicity events associated with antibiotics approved since 2018.
Panagiotis Stathopoulos, Laura T. Romanos, Charalampos Loutradis, Matthew E. Falagas   +3 more
doaj   +1 more source

Durlobactam to boost the clinical utility of standard of care β-lactams against Mycobacterium abscessus lung disease

Antimicrobial Agents and Chemotherapy
ABSTRACT β-Lactams present several desirable pharmacodynamic features leading to the rapid eradication of many bacterial pathogens. Imipenem (IPM) and cefoxitin (FOX) are injectable β-lactams recommended during the intensive treatment phase of pulmonary infections caused by Mycobacterium ...
Dereje A. Negatu, Wassihun Wedajo Aragaw, Tewodros T. Gebresilase, Sindhuja Paruchuri, Firat Kaya, Sung Jae Shin, Peter Sander, Véronique Dartois, Thomas Dick   +8 more
openaire   +2 more sources

Current Advances in Developing New Antimicrobial Agents Against Non-Tuberculous Mycobacterium

Antibiotics
Non-tuberculous mycobacteria (NTM) comprise more than 190 species capable of causing severe pulmonary, lymphatic, cutaneous, and disseminated infections, particularly in immunocompromised populations.
Jane Cross, Nupur Gargate, Khondaker Miraz Rahman   +2 more
doaj   +1 more source

The Role of Combination Antibiotic Therapy in Combatting Drug-Resistant Acinetobacter baumannii Infections: A Systematic Review of Randomised Control Trials

Antibiotics
Background: Acinetobacter baumannii is a major global health threat due to its rapid acquisition of multidrug resistance, particularly to carbapenems.
Anteneh Assefa Gezmu, Abel Workalemahu Tesfaye, Anthony R. M. Coates   +2 more
doaj   +1 more source

Beta-lactamase inhibitors - an effective way to combat antibiotic resistance [PDF]

Introducere. Creşterea rezistenţei microbilor la antibiotice constituie o problemă de sănătate publică. Una din cauzele majore ale rezistenţei la beta-lactamine s-a raportat a fi producerea de beta-lactamaze.
Lehevici, Ion
core  

Novel Insights into Carbapenem Resistance: Mechanisms, Diagnostics, and Future Directions

Antibiotics
Carbapenems are essential for the treatment of severe infections caused by Gram-negative bacteria, particularly in critically ill and immunocompromised patients.
Ionela-Larisa Miftode, Viorel Dragoș Radu, Raul-Alexandru Jigoranu, Daniela-Anicuța Leca, Cristian Sorin Prepeliuc, Maria Antoanela Pasare, Radu-Stefan Miftode, Maria Gabriela Grigoriu, Tudorița Gabriela Parângă, Egidia Gabriela Miftode   +9 more
doaj   +1 more source

Global trends in carbapenem-resistant gram-negative bacteria research (2020–2025): a bibliometric analysis and systematic review

Frontiers in Cellular and Infection Microbiology
BackgroundCarbapenem-resistant Gram-negative bacteria (CRGNB) pose a severe global health threat, yet comprehensive bibliometric analyses in this field remain limited.
Xiaotong Zhang, Xiaotong Zhang, Xiaotong Zhang, Ce Zhang, Ce Zhang, Ce Zhang, Mengyao Lv, Mengyao Lv, Mengyao Lv, Shu Wang, Shu Wang, Shu Wang, Qiuting Wang, Qiuting Wang, Qiuting Wang, Chengshuai Yang, Chengshuai Yang, Chengshuai Yang, Qian Zhao, Luyuan Ma, Luyuan Ma, Luyuan Ma, Bei Li, Xiaohua Qin, Caiyan Zhao, Caiyan Zhao, Caiyan Zhao, Chuan Shen, Chuan Shen, Chuan Shen   +29 more
doaj   +1 more source