Results 161 to 170 of about 71,444 (299)

RUBIES: JWST/NIRSpec Confirmation of an Infrared-luminous, Broad-line Little Red Dot with an Ionized Outflow

The Astrophysical Journal
The JWST discovery of “little red dots” (LRDs) is reshaping our picture of the early Universe, yet the physical mechanisms driving their compact size and UV-optical colors remain elusive.
Bingjie Wang, Anna de Graaff, Rebecca L. Davies, Jenny E. Greene, Joel Leja, Gabriel B. Brammer, Andy D. Goulding, Tim B. Miller, Katherine A. Suess, Andrea Weibel, Christina C. Williams, Rachel Bezanson, Leindert A. Boogaard, Nikko J. Cleri, Michaela Hirschmann, Harley Katz, Ivo Labbé, Michael V. Maseda, Jorryt Matthee, Ian McConachie, Rohan P. Naidu, Pascal A. Oesch, Hans-Walter Rix, David J. Setton, Katherine E. Whitaker   +24 more
doaj   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Resolving the Dusty Star-forming Galaxy GN20 at z = 4.055 with NOEMA and JWST: A Similar Distribution of Stars, Gas, and Dust Despite Distinct Apparent Profiles

The Astrophysical Journal
We present high-resolution (0 $\mathop{.}\limits^{^{\prime\prime} }$ 13–0 $\mathop{.}\limits^{^{\prime\prime} }$ 23) NOEMA observations of the dust continuum emission at 1.1 mm (rest frame 220 μ m) and JWST/NIRCam and MIRI imaging of the z = 4.055 ...
Leindert A. Boogaard, Fabian Walter, Axel Weiß, Luis Colina, Jacqueline Hodge, Arjan Bik, Alejandro Crespo Gómez, Emanuele Daddi, Georgios E. Magdis, Romain A. Meyer, Göran Östlin   +10 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Assessing the Cosmic Infrared Background Monopole from Far-infrared to Millimeter Wavelengths

The Astrophysical Journal
We measured the cosmic infrared background (CIB) monopole for the COBE Diffuse Infrared Background Experiment (DIRBE) and Planck High-Frequency Instrument (HFI) bands with an updated model for the Galactic dust emission. This model includes a dust excess
Jean-Marc Casandjian, Jean Ballet, Isabelle Grenier   +2 more
doaj   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

High resolution sub-millimetre mapping of starburst galaxies: Comparison with CO emission [PDF]

Researchers present first results from a program of submillimeter continuum mapping of starburst galaxies, and comparison of their dust and CO emission.
Brand, P. W. J. L., Mountain, C. M., Nakai, Naomasa, Puxley, Phil J., Smith, P. A.   +4 more
core   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source