Results 141 to 150 of about 1,574,380 (286)

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Scylla: Observational Evidence for an Order of Magnitude in Dust-mass Opacity Evolution with Interstellar Medium Density in the Large Magellanic Cloud

The Astrophysical Journal Letters
The emissivity of dust is known to vary greatly with radiative environment, density, grain chemistry, and geometry. Discrepancies between dust-mass surface densities derived from far-infrared (FIR) emission and visible extinction persist across and ...
Christina W. Lindberg, Christopher J. R. Clark, Claire E. Murray, Julia Roman-Duval, Caroline Bot, Yumi Choi, Roger E. Cohen, Steven R. Goldman, Karl D. Gordon, Kristen B. W. McQuinn, Elizabeth Tarantino, Benjamin F. Williams, Petia Yanchulova Merica-Jones, Catherine Zucker   +13 more
doaj   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

The ALMA Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO). X. Dust Substructures, Disk Geometries, and Dust-disk Radii

The Astrophysical Journal
We perform visibility fitting to the dust continuum Band 6 1.3 mm data of the 30 protoplanetary disks in the Atacama Large Millimeter/submillimeter Array Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO) Large Program.
Miguel Vioque, Nicolás T. Kurtovic, Leon Trapman, Anibal Sierra, Laura M. Pérez, Ke Zhang, Pietro Curone, Giovanni P. Rosotti, John Carpenter, Benoît Tabone, Paola Pinilla, Dingshan Deng, Ilaria Pascucci, James Miley, Carolina Agurto-Gangas, Lucas A. Cieza, Rossella Anania, Dary A. Ruiz-Rodriguez, Camilo González-Ruilova, Estephani E. TorresVillanueva, Aleksandra Kuznetsova   +20 more
doaj   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

Testing He ii Emission from Wolf–Rayet Stars as a Dust Attenuation Measure in Eight Nearby Star-forming Galaxies

The Astrophysical Journal
The ability to determine galaxy properties such as masses, ages, and star formation rates robustly is critically limited by the ability to measure dust attenuation accurately.
Daniel Maschmann, Claus Leitherer, Andreas L. Faisst, Janice C. Lee, Rebecca Minsley   +4 more
doaj   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Hints of Disk Substructure in the First Brown Dwarf with a Dynamical Mass Constraint

The Astrophysical Journal Letters
We present high-resolution Atacama Large Millimeter/submillimeter Array (ALMA) observations at 0.89 mm of the Class II brown dwarf 2MASS J04442713+2512164 (2M0444), achieving a spatial resolution of 0 $\mathop{.}\limits^{^{\prime\prime} }$ 046 (∼6.4 au ...
Alejandro Santamaría-Miranda, Pietro Curone, Laura Pérez, Nicolas T. Kurtovic, Carolina Agurto-Gangas, Anibal Sierra, Itziar de Gregorio-Monsalvo, Nuria Huélamo, James M. Miley, Aina Palau, Paola Pinilla, Isabel Rebollido, Álvaro Ribas, Pablo Rivière-Marichalar, Matthias R. Schreiber, Jinshi Sai, Benjamín Carrera   +16 more
doaj   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source