Results 151 to 160 of about 71,444 (299)
Hints of Disk Substructure in the First Brown Dwarf with a Dynamical Mass Constraint
The Astrophysical Journal LettersWe present high-resolution Atacama Large Millimeter/submillimeter Array (ALMA) observations at 0.89 mm of the Class II brown dwarf 2MASS J04442713+2512164 (2M0444), achieving a spatial resolution of 0 $\mathop{.}\limits^{^{\prime\prime} }$ 046 (∼6.4 au ...
Alejandro Santamaría-Miranda +16 more
doaj +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Variations in the spatial distribution of 11 Micron radiation from omicron Ceti [PDF]
The spatial distribution of 11 micron radiation from omicron Ceti was observed at various phases of its light cycle using a stellar interferometer.
Spears, D. L. +3 more
core +1 more source
Structure and chemistry in the northwestern condensation of the Serpens molecular cloud core [PDF]
, 1994 We present single-dish and interferometric observations of gas and dust in the core of the Serpens molecular cloud, focusing on the northwestern condensation.
Blake, Geoff A. +4 more
core
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
ALMA High-resolution Observation for the Transitional Disk Around IRAS 04125+2902
The Astrophysical JournalRecently, the youngest transiting planet was discovered around the T Tauri star, IRAS 04125+2902, in the Taurus-Auriga star-forming region. This system is crucial for understanding the early stages of planet formation.
Ayumu Shoshi +7 more
doaj +1 more source
Advanced Science, EarlyView.The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu +9 more
wiley +1 more source
A 2 au Resolution View by ALMA of the Planet-hosting WISPIT 2 Disk
The Astrophysical Journal LettersWe present deep, high-spatial-resolution interferometric observations of 0.88 mm continuum emission from the TYC 5709-354-1 system, hereafter WISPIT 2, obtained with the goal of detecting circumplanetary emission in the vicinity of the newly discovered ...
Stefano Facchini +6 more
doaj +1 more source
Advanced Science, EarlyView.A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu +12 more
wiley +1 more source