Results 71 to 80 of about 4,700 (187)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

Advanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos, Laia Bagur, Cristina Vaca, Aritz Lafuente, Joaquin Llacer‐Wintle, Bojan Ambrožič, Christina Stefani, Minsoo Kim, Goran Dražić, Darja Lisjak, Jordi Sort, Xiang‐Zhong Chen, Maria Jose Esplandiu, Salvador Pané, Carme Nogués, Josep Nogués, Andreu Blanquer, Borja Sepúlveda   +17 more
wiley   +1 more source

Synthesis imaging of the DR 21(OH) cluster. I - Dust continuum and C(O-18) emission

The Astrophysical Journal, 1991
Maps at 7″ resolution of 2.7 mm continuum and J=1→0 C 18 O emission have been made of the DR 21(OH) molecular cloud core. Three compact regions, all of which appear to be actively forming stars, have been detected. Two components, each measuring ∼12,000 AU in size, containing ∼400-500 M ⊙ of material and encompassing H 2 O masers, dominate the most ...
Jeffrey G. Mangum, Alwyn Wootten, Lee G. Mundy   +2 more
openaire   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Early Science with the Large Millimeter Telescope : observations of dust continuum and CO emission lines of cluster-lensed submillimetre galaxies at z=2.0-4.7

, 2015
We present Early Science observations with the Large Millimeter Telescope, AzTEC 1.1 mm continuum images and wide bandwidth spectra (73–111 GHz) acquired with the Redshift Search Receiver, towards four bright lensed submillimetre galaxies identified ...
Chapman, S.C., Geach, J.E., M. Dessauges-Zavadsky (7636439), Wilner, D.J., Swinbank, A.M., Blain, A.W., Zeballos, M., G. W. Wilson (7636430), J. E. Geach (7621910), Zavala, J.A., D. J. Wilner (7636436), Egami, E., Dessauges-Zavadsky, M., Sánchez-Argüelles, D., A. Montana (7636442), Edge, A.~C., Yun, M.~S., Wilson, G.W., M. S. Yun (7636427), Gurwell, M.A., Webb, T.M.A., E. Egami (7601402), Coppin, K.E.K., Geach, J.~E., K. E. K. Coppin (7603334), Blain, A.~W., Yun, M.S., Rawle, T.D., S. C. Chapman (7601474), Edge, A.C., Andrew William Blain (7635698), Hughes, D.~H., T. M. A. Webb (7636454), I. Aretxaga (7599950), Zavala, J.~A., D. H. Hughes (7601873), D. Sanchez-Argueelles (7636451), Webb, T.~M.~A., Nakajima, K., J. A. Zavala (7626992), Hughes, D.H., A. M. Swinbank (7603247), Montaña, A., I. Smail (7599914), Swinbank, A.~M., Aretxaga, I., M. A. Gurwell (7636433), M. Zeballos (7636457), A. C. Edge (7603229), Gurwell, M.~A., T. D. Rawle (7636448), Rawle, T.~D., K. Nakajima (7636445), Coppin, K.~E.~K., Wilson, G.~W., Wilner, D.~J., Chapman, S.~C., Smail, I.   +57 more
core   +1 more source

Mapping dust through emission and absorption in nearby galaxies [PDF]

, 2013
Dust has long been identified as a barrier to measuring inherent galaxy properties. However, the link between dust and attenuation is not straightforward and depends on both the amount of dust and its distribution.
Draine, Bruce T, Dale, Daniel A., Groves, Brent, Crocker, Alison F., Dale, Daniel A, Kennicutt, Robert C, Hunt, Leslie K, Aniano, Gonzalo, van der Wel, Sharon Meidt, Johnson, Benjamin D., Johnson, Benjamin D, Calzetti, Daniela, Tabatabaei, Fatemeh S, Draine, Bruce T., Smith, J. D. T., Schinnerer, Eva, Gordon, Karl D, Kennicutt, Robert C., Tabatabaei, Fatemeh S., Crocker, Alison F, Croxall, Kevin V., Kreckel, Kathryn, Smith, JDT, Gordon, Karl D., Croxall, Kevin V, Meidt, Sharon E., Hunt, Leslie K.   +26 more
core   +1 more source

Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays

Advanced Science, EarlyView.
An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen, Bin Li, Yingying Wang, Fulin Zhu, Wenxuan Yang, Xuanyu Fu, Tiantian Man, Qiuyue Wu, Kewei Ren, Shengyuan Deng   +9 more
wiley   +1 more source

Longwave spectral dependence of emission from warm dust clouds

, 1989
Observations of the continuum emission from warm dust clouds at 230 GHz, or 1300 microns, enables the determination of the frequency dependence of the optically thin longwave emission.
Gordon, M. A.
core  

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source