Results 81 to 90 of about 1,668 (251)

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Interpreting ALMA Multiwavelength Continuum Observations of PDS 70 c: An Optically Thick Dust Ring in the Circumplanetary Disk

The Astrophysical Journal Letters
Giant planets form small gas disks, called circumplanetary disks (CPDs), during gas accretion. The CPD of PDS 70 c has been detected by the Atacama Large Millimeter/submillimeter Array in (sub)millimeter continuum emission, which is interpreted as ...
Yuhito Shibaike, Satoshi Okuzumi, Takahiro Ueda, Kiyoaki Doi, Misato Fukagawa   +4 more
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Multiwavelength ALMA Imaging of HD 34282: Dust-trapping Signatures of a Vortex Candidate

The Astrophysical Journal
Azimuthal arcs in millimeter continuum emission from protoplanetary disks are often attributed to dust-trapping vortices, but definitive observational confirmation of vortices remains lacking.
Xiaoyi Ma, Fangyuan Yu, Ruobing Dong, Kiyoaki Doi, Akimasa Kataoka, Hauyu Baobab Liu, Feng Long, Takahiro Ueda, Huojun Li, Nienke van der Marel, Ágnes Kóspál   +10 more
doaj   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Subtle and Spectacular: Diverse White Dwarf Debris Disks Revealed by JWST

The Astrophysical Journal Letters
This Letter reports 12 novel spectroscopic detections of warm circumstellar dust orbiting polluted white dwarfs using the JWST Mid-Infrared Instrument (MIRI). The disks span 2 orders of magnitude in fractional infrared brightness and more than double the
J. Farihi, K. Y. L. Su, C. Melis, S. J. Kenyon, A. Swan, S. Redfield, M. C. Wyatt, J. H. Debes   +7 more
doaj   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

First JVLA Radio Observation on PDS 70

The Astrophysical Journal
PDS 70 is a protoplanetary system that hosts two actively accreting gas giants, namely, PDS 70b and PDS 70 c. The system has a ∼60–100 au dusty ring that has been resolved by the Atacama Large Millimeter/Submillimeter Array (ALMA), along with ...
Hauyu Baobab Liu, Simon Casassus, Ruobing Dong, Kiyoaki Doi, Jun Hashimoto, Takayuki Muto   +5 more
doaj   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

exoALMA. XI. ALMA Observations and Hydrodynamic Models of LkCa 15: Implications for Planetary Mass Companions in the Dust Continuum Cavity

The Astrophysical Journal Letters
In the past decade, the Atacama Large Millimeter/submillimeter Array (ALMA) has revealed a plethora of substructures in the disks surrounding young stars.
Charles H. Gardner, Andrea Isella, Hui Li, Shengtai Li, Jaehan Bae, Marcelo Barraza-Alfaro, Myriam Benisty, Gianni Cataldi, Pietro Curone, Josh A. Eisner, Stefano Facchini, Daniele Fasano, Mario Flock, Katherine B. Follette, Misato Fukagawa, Maria Galloway-Sprietsma, Himanshi Garg, Cassandra Hall, Jane Huang, John D. Ilee, Michael J. Ireland, Andrés F. Izquierdo, Christopher M. Johns-Krull, Kazuhiro Kanagawa, Adam L. Kraus, Geoffroy Lesur, Shangfei Liu, Cristiano Longarini, Ryan A. Loomis, Francois Menard, Ryuta Orihara, Christophe Pinte, Daniel Price, Luca Ricci, Giovanni Rosotti, Steph Sallum, Jochen Stadler, Richard Teague, Gaylor Wafflard-Fernandez, David J. Wilner, Andrew J. Winter, Lisa Wölfer, Hsi-Wei Yen, Tomohiro C. Yoshida, Brianna Zawadzki, Zhaohuan Zhu   +45 more
doaj   +1 more source