Results 101 to 110 of about 1,574,380 (286)

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Physical and Chemical Characterization of GY 91’s Multi-ringed Protostellar Disk with ALMA

The Astrophysical Journal
GY 91, commonly categorized as a Class I young stellar object, is notable for disk dust substructures that have been hypothesized to trace early planet formation.
Sally D. Jiang, Jane Huang, Ian Czekala, Leon Trapman, Yuri Aikawa, Sean M. Andrews, Jaehan Bae, Edwin A. Bergin, Charles J. Law, Romane Le Gal, Feng Long, François Ménard, Karin I. Öberg, Chunhua Qi, Richard Teague, David J. Wilner, Ke Zhang   +16 more
doaj   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

The Evolution in Coma Molecular Composition of Comet C/2017 K2 (PanSTARRS) across the H2O Sublimation Zone: ALMA Imaging of a H2O-dominated Coma

The Planetary Science Journal
We report a survey of molecular emission from cometary volatiles using the Atacama Large Millimeter/submillimeter Array toward comet C/2017 K2 (PanSTARRS) carried out on UT 2022 September 21, 22, and 23 at a heliocentric distance ( r _H ) of 2.1 au ...
Nathan X. Roth, Stefanie N. Milam, Martin A. Cordiner, Anthony J. Remijan, Dominique Bockelée-Morvan, Nicolas Biver, Jérémie Boissier, Steven B. Charnley, Charles E. Woodward, Lillian X. Hart, Timothy N. Proudkii   +10 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

exoALMA. VI. Rotating under Pressure: Rotation Curves, Azimuthal Velocity Substructures, and Gas Pressure Variations

The Astrophysical Journal Letters
The bulk motion of the gas in protoplanetary disks around newborn stars is nearly Keplerian. By leveraging the high angular and spectral resolution of the Atacama Large Millimeter/submillimeter Array (ALMA), we can detect small-scale velocity ...
Jochen Stadler, Myriam Benisty, Andrew J. Winter, Andrés F. Izquierdo, Cristiano Longarini, Maria Galloway-Sprietsma, Pietro Curone, Sean M. Andrews, Jaehan Bae, Stefano Facchini, Giovanni Rosotti, Richard Teague, Marcelo Barraza-Alfaro, Gianni Cataldi, Nicolás Cuello, Ian Czekala, Daniele Fasano, Mario Flock, Misato Fukagawa, Himanshi Garg, Cassandra Hall, Iain Hammond, Thomas Hilder, Jane Huang, John D. Ilee, Kazuhiro Kanagawa, Geoffroy Lesur, Giuseppe Lodato, Ryan A. Loomis, Francois Menard, Ryuta Orihara, Christophe Pinte, Daniel J. Price, Hsi-Wei Yen, Gaylor Wafflard-Fernandez, David J. Wilner, Lisa Wölfer, Tomohiro C. Yoshida, Brianna Zawadzki   +38 more
doaj   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

GATOS. VIII. On the Physical Origin of the Extended Mid-infrared Emission in Active Galactic Nuclei

The Astrophysical Journal
The polar mid-infrared (MIR) emission detected within tens to hundreds of parsecs in some active galactic nuclei (AGN) has been associated with dusty winds driven away by radiation pressure.
Enrique Lopez-Rodriguez, Cristina Ramos Almeida, Miguel Pereira-Santaella, Ismael García-Bernete, Robert Nikutta, Almudena Alonso-Herrero, Anelise Audibert, Enrica Bellocchi, Andrew Bunker, Steph Campbell, Françoise Combes, Richard Davies, Tanio Diaz-Santos, Lindsay Fuller, Poshak Gandhi, Santiago García-Burillo, Omaira González-Martín, Erin K. S. Hicks, Sebastian Hönig, Kohei Ichikawa, Masatoshi Imanishi, Takuma Izumi, Alvaro Labiano, Nancy A. Levenson, Christopher Packham, David Rosario, Dimitra Rigopoulou, Daniel Rouan, Taro Shimizu, Marko Stalevski, Martin Ward, Lulu Zhang, Claudio Ricci, Donaji Esparza-Arredondo, Begoña García-Lorenzo   +34 more
doaj   +1 more source

Measuring the star formation rate density from CNOC2 [PDF]

, 2006
This thesis charts the evolution of the Universal Star Formation Rate Density (SFRD) across the redshift range 0.2 < z < 0.6, using the 2nd Canadian Network for Observational Cosmology Survey (CN0C2).
Whitaker, Richard James
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