Results 111 to 120 of about 1,574,380 (286)

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Interpreting ALMA Multiwavelength Continuum Observations of PDS 70 c: An Optically Thick Dust Ring in the Circumplanetary Disk

The Astrophysical Journal Letters
Giant planets form small gas disks, called circumplanetary disks (CPDs), during gas accretion. The CPD of PDS 70 c has been detected by the Atacama Large Millimeter/submillimeter Array in (sub)millimeter continuum emission, which is interpreted as ...
Yuhito Shibaike, Satoshi Okuzumi, Takahiro Ueda, Kiyoaki Doi, Misato Fukagawa   +4 more
doaj   +1 more source

Anomalous Microwave Emission from Star Forming Regions

Advances in Astronomy, 2013
The evidence for microwave emission from spinning dust grains has been strengthened considerably by its detection in a number of discrete astrophysical objects associated with star formation.
Anna M. M. Scaife
doaj   +1 more source

Far-Infrared Emission from Dust in Normal Galaxies

, 2003
We review the morphological and spectral energy distribution characteristics of the dust continuum emission (emitted in the 40-200 {μ}m spectral range) from normal galaxies, as revealed by detailed ISOPHOT mapping observations of nearby spirals and by ...
Tuffs, R., Popescu, C.
core  

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Multiwavelength ALMA Imaging of HD 34282: Dust-trapping Signatures of a Vortex Candidate

The Astrophysical Journal
Azimuthal arcs in millimeter continuum emission from protoplanetary disks are often attributed to dust-trapping vortices, but definitive observational confirmation of vortices remains lacking.
Xiaoyi Ma, Fangyuan Yu, Ruobing Dong, Kiyoaki Doi, Akimasa Kataoka, Hauyu Baobab Liu, Feng Long, Takahiro Ueda, Huojun Li, Nienke van der Marel, Ágnes Kóspál   +10 more
doaj   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Subtle and Spectacular: Diverse White Dwarf Debris Disks Revealed by JWST

The Astrophysical Journal Letters
This Letter reports 12 novel spectroscopic detections of warm circumstellar dust orbiting polluted white dwarfs using the JWST Mid-Infrared Instrument (MIRI). The disks span 2 orders of magnitude in fractional infrared brightness and more than double the
J. Farihi, K. Y. L. Su, C. Melis, S. J. Kenyon, A. Swan, S. Redfield, M. C. Wyatt, J. H. Debes   +7 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Appendices to "ATOMIUM: Continuum emission and evidence of dust enhancement from binary motion"

Appendices A through H to the A&A publication "ATOMIUM: Continuum emission and evidence of dust enhancement from binary motion" by T. Danilovich, N. Samaratunge, Y. Mori, A. M. S. Richards, A. Baudry, S. Etoka, M. Montargès, P. Kervella, I. McDonald, C. A. Gottlieb, A. Wallace, D. J. Price, L. Decin, J. Bolte, T. Ceulemans, F. De Ceuster, A.
openaire   +2 more sources