Results 41 to 50 of about 574,820 (241)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Observational Evidence of Dust Evolution in Supernova Remnants: Size Redistribution toward Larger Grains in the Early Sedov Phase

The Astrophysical Journal Letters
Recent observations have revealed that dust is widespread and abundant in galaxies up to z  ≃ 8, significantly influencing their appearance and spectral properties.
He Zhao, Bingqiu Chen, Jun Li
doaj   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

Toward a General Theory of Grain Alignment and Disruption by Radiative Torques and Magnetic Relaxation

The Astrophysical Journal
We generalize the magnetically enhanced radiative torque (MRAT) theory for astrophysical environments described by a dimensionless parameter U /( n _1 T _2 ) with U the radiation strength, n _1  =  n _H /(10 cm ^−3 ) the normalized hydrogen density, and ...
Thiem Hoang
doaj   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Carbonaceous dust processing in the merger galaxy II Zw 096: High-resolution polycyclic aromatic hydrocarbon diagnostics with JWST

Astronomy & Astrophysics
Context. Galaxy mergers drive intense radiation environments that fundamentally alter interstellar dust properties through photo-destruction and thermal processing.
Olander Gustav, Schirmer Thiebaut, Aalto Susanne, del Palacio Santiago, Diaz-Santos Tanio, Inami Hanae, Armus Lee, Buiten Victorine, Knudsen Kirsten K., König Sabine, Lai Thomas S.-Y., Lenkic Laura, Linden Sean T., Nyman Gunnar, Riesco Clemente, van der Werf Paul, Vlemmings Wouter, Sameera W. M. C., Wethers Clare   +18 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

JOYS: Launch and destruction of dust in protostellar jets

Astronomy & Astrophysics
Context. Protostellar winds can theoretically lift solids from the planet-forming disks, but direct evidence for launched dust has been scarce so far. Numerous atomic lines that are unique to mid-infrared (IR) wavelengths reveal refractories eroded from ...
Tychoniec Łukasz, Francis Logan, Navarro Maria Gabriela, Vorster Jakobus M., van Dishoeck Ewine F., Caratti o Garatti Alessio, Assani Korash, Le Gouellec Valentin J. M., Tabone Benoît, Klaassen Pamela, Janssen Adriaan G. M., Justtanont Kay, Harsono Daniel, Nazari Pooneh, Reyes-Reyes Simon D., Slavicinska Katerina, Gieser Caroline, Bourke Tyler L., Yang Yao-Lun, Nisini Brunella, Giannini Teresa, Beuther Henrik, Devaraj R., Ray Thomas P., Brunken Nashanty G. C., Chen Yuan, van Gelder Martijn L.   +26 more
doaj   +1 more source