Results 61 to 70 of about 574,820 (241)

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Mechanical Properties of Dust, Pebbles, and Planetesimals Based on Johnson–Kendall–Roberts, Griffith, and Weibull Theories

The Astrophysical Journal
Mechanical properties of small bodies such as dust, pebbles, and planetesimals are key to better understanding the formation of planetary systems against their collisional destruction.
Hiroshi Kimura, Takaya Okamoto, Takayuki Hirai, Fumi Yoshida, Peng K. Hong, Koji Wada, Tomoko Arai, Eiichiro Kokubo, Yuki Yoshida, Toshihiko Kadono, Sota Arakawa, Hiroki Senshu, Masanori Kobayashi, Ko Ishibashi, Manabu Yamada, Hiroshi Akitaya, Osamu Okudaira, Takafumi Matsui   +17 more
doaj   +1 more source

Dust evolution across cosmic times as seen through DUSTY-GAEA

Astronomy & Astrophysics
For many decades, dust has been recognised as an important ingredient in galaxy formation and evolution. This paper presents a novel self-consistent implementation of dust formation by stars, destruction by supernova shocks and hot gas, and growth within
Osman Omima, De Lucia Gabriella, Fontanot Fabio, Xie Lizhi, Hirschmann Michaela   +4 more
doaj   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Dust Evolution in Simulated Multiphase Galactic Outflows

The Astrophysical Journal
We present the first large-scale, high-resolution simulations of dusty, star formation feedback-driven galactic outflows. Using the Cholla hydrodynamics code, we investigate dust sputtering in these environments for grains ranging in size from 1 to 0.001
Helena M. Richie, Evan E. Schneider
doaj   +1 more source

Enhanced Endophytic Colonization of Flavobacterium Promotes Plant Resistance to Fusarium Wilt

Advanced Science, EarlyView.
A natural microbial consortium employing a cross‐feeding strategy forms a stratified biofilm that promotes endophytic colonization of auxotrophic Flavobacterium. This enhanced colonization activates plant systemic resistance, effectively suppressing Fusarium wilt.
Xianfeng Ye, Changsheng Xu, Shuai Yao, Jiming Shen, Zeyuan Li, Yu Zhang, Fan Wu, Xinjie Li, Yanling Ji, Lei Zhang, Yan Huang, Zhoukun Li, Huayu Qin, Zhongli Cui   +13 more
wiley   +1 more source

Dust Formation in Milky Way-like Galaxies [PDF]

, 2016
We introduce a dust model for cosmological simulations implemented in the moving-mesh code arepo and present a suite of cosmological hydrodynamical zoom-in simula-tions to study dust formation within galactic haloes.
Mark Vogelsberger, Paul Torrey, Ryan Mckinnon   +2 more
core   +2 more sources

Tensile Strength of Dust, Pebbles, and Planetesimals: A Simple Mathematical Formula from Aggregates to Monoliths Based on an Extension of an Elastic Theory for Particle Assemblies to Molecular Networks

The Astrophysical Journal
The tensile strength of solid particles is the key parameter that controls not only the formation of planetesimals in protoplanetary disks but also outburst and splitting of comets and rotational bursting of asteroids in planetary systems.
Hiroshi Kimura, Takayuki Hirai, Takaya Okamoto, Akiko M. Nakamura, Eiichiro Kokubo, Yuki Yoshida, Fumi Yoshida, Peng K. Hong, Koji Wada, Hiroki Senshu, Tomoko Arai, Sota Arakawa, Toshihiko Kadono, Masanori Kobayashi, Ko Ishibashi, Hiroshi Akitaya, Manabu Yamada, Osamu Okudaira, Takafumi Matsui   +18 more
doaj   +1 more source

Major factors influencing local dust radiative forcing [PDF]

, 2008
In conclusion, it is shown in this paper that surface albedo variations over desert regions can have a significant influence on the solar and net radiative forcing of desert dust.
Otto, Sebastian, Bierwirth, Eike, Bauer, Stefan, Trautmann, Thomas, Wendisch, Manfred   +4 more
core  

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source