Results 91 to 100 of about 4,735 (197)

Systematic review evaluating cardiovascular events of the 5-alpha reductase inhibitor - Dutasteride

, 2013
A recently published large, long-term randomized controlled trial (RCT) brought into question the safety of dutasteride after a significantly increased risk of 'cardiac failure' was noted in the dutasteride arm of the trial compared with placebo.
Loke, Y K, Sage, W, Singh, S, Sandhu, M, Ho, R, Smith, M, Wong, O   +6 more
core   +1 more source

Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

The World Journal of Men's Health, 2019
Purpose: The current study is aimed to assess whether a longer duration of 5α-reductase inhibitor (5α-RI) exposure was asso-ciated with higher rate of permanent erectile dysfunction (ED) in a rat model.
Hyun Hwan Sung, Jiwoong Yu, Su Jeong Kang, Mee Ree Chae, Insuk So, Jong Kwan Park, Sung Won Lee   +6 more
doaj   +1 more source

EFFECTIVENESS OF 5-ALPHA-REDUCTASE INHIBITORS IN PATIENTS WITH PROSTATIC INTRAEPITHELIAL NEOPLASIA OF PERIPHERAL PROSTATE ZONE

Східноукраїнський медичний журнал, 2019
Prostate intraepithelial neoplasia (PIN) is a widespread pathologic state, which in 16–25 % cases leads to prostate cancer (PC). Today specific operative and medicated methods of PIN treatment are not developed. The aim of PIN treatment represents at the
M. P. Мelnychuk
doaj  

A comparison of the efficacy of dutasteride on reducing lower urinary tract symptoms among patients with small versus large benign prostatic hyperplasia

Current Urology
. Background. Only a few reports have currently studied the efficacy of dutasteride in patients with small benign prostatic hyperplasia (BPH). We investigated the efficacy of dutasteride on reducing lower urinary tract symptoms among them.
Kazuyoshi Shigehara, Yuki Kato, Shohei Kawaguchi, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami   +5 more
doaj   +1 more source

The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopecia

, 2014
BACKGROUND: The effectiveness of finasteride and dutasteride in women with androgenetic alopecia has been the subject of debate. AIM: To evaluate the effectiveness of finasteride and dutasteride on hair loss in women with androgenetic alopecia over a ...
IORIZZO, MATILDE, ArnoldP Oranje, PIRACCINI, BIANCA MARIA, IdsH Boersma, Ramon Grimalt, EmielH Verdonschot   +5 more
core   +1 more source

Effectiveness and Safety of Combined Therapy with Oral Minoxidil, Oral Dutasteride, and Mesotherapy with Dutasteride in Real Clinical Practice

Background: Androgenetic alopecia (AGA) is the most prevalent form of hair loss in humans. Oral minoxidil and dutasteride are widely used treatments, while intradermal dutasteride mesotherapy has recently gained interest as a complementary approach ...
Juan Francisco Molina-de la Garza, César Daniel Villarreal-Villarreal, Carolina Gonzalez-Macias, David Saceda-Corralo, Sergio Vano-Galvan, Estefanía Boland-Rodriguez   +5 more
core   +1 more source

The Potential of Dutasteride for Treating Multidrug-Resistant Candida auris Infection

Pharmaceutics
Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen Candida auris. In this study, the most cost-effective drug repurposing technology was adopted to identify an appropriate option ...
J. Francis Borgio, Noor B. Almandil, Prathas Selvaraj, J. Sherlin John, Rahaf Alquwaie, Eman AlHasani, Norah F. Alhur, Razan Aldahhan, Reem AlJindan, Dana Almohazey, Sarah Almofty, T. Stalin Dhas, Sayed AbdulAzeez   +12 more
doaj   +1 more source

Dutasteride: A Review of its Use in the Management of Prostate Disorders

, 2011
Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes approved for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate ...
E. David Crawford, Garrett D. Pohlman, Emily A. Pohlman   +2 more
core   +1 more source

Cost Utility of Prostate Cancer Chemoprevention with Dutasteride in Men with an Elevated Prostate Specific Antigen

, 2011
Background: In the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial, dutasteride reduced the relative risk of prostate cancer (CaP) diagnosis over a 4-year period by 22.8%, but questions remain regarding the cost–effectiveness of ...
Yair Lotan, Robert S. Svatek
core   +1 more source

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

Drug Design, Development and Therapy, 2015
In-hwan Baek,1,* Eun-Sol Ha,2,* Jin-Wook Yoo,2 Yunjin Jung,2 Min-Soo Kim21College of Pharmacy, Kyungsung University, 2College of Pharmacy, Pusan National University, Busan, Republic of Korea*These authors contributed equally to this workAbstract: In this
Baek I, Ha ES, Yoo JW, Jung Y, Kim MS
doaj