Dydrogesterone and Letrozole Combination for the Treatment of Endometriosis: A Mechanism-Based Therapeutic Approach [PDF]
Endometriosis is a complex, estrogen-dependent disease with limited effective treatments that often focus on symptom management rather than addressing the underlying pathology.
Santosh Kumar Rai +3 more
doaj +3 more sources
Effectiveness of oral dydrogesterone compared to placebo in reducing the risk of preterm birth: a systematic review and meta-analysis [PDF]
Background Preterm birth remains a major contributor to neonatal morbidity and mortality worldwide. Oral dydrogesterone is used in some clinical settings for preterm birth prevention, despite uncertainty regarding its effectiveness.
Sohieb Hedawy +6 more
doaj +2 more sources
Efficacy and safety of estradiol/dydrogesterone combined with escitalopram in the treatment of anxiety and depression in perimenopausal women: a randomized controlled trial [PDF]
BackgroundTo investigate the efficacy and underlying mechanisms of a combined therapy of estradiol/dydrogesterone and escitalopram in treating perimenopausal anxiety and depression.MethodsA total of 195 patients were randomized to receive escitalopram ...
Shufang Wu +36 more
doaj +2 more sources
Age-stratified analysis of euploidy rates in Progestin-Primed Ovarian Stimulation (PPOS) utilizing micronized progesterone or dydrogesterone versus GnRH analogues [PDF]
Purposes This study aims to analyze the euploidy rates of PPOS utilizing micronized progesterone and dydrogesterone in comparison to conventional controlled ovarian stimulation (COS) protocols in pre-implantation genetic testing for aneuploidy (PGT-A ...
Rang Liu +8 more
doaj +2 more sources
Gu Ben An Tai decoction combined with dydrogesterone for early threatened abortion secondary to spleen and kidney deficiency: a retrospective observational study [PDF]
Background In this retrospective observational study, we aimed to evaluate the clinical efficacy and safety of Gu Ben An Tai Decoction (GBATD) combined with dydrogesterone for treating threatened abortion (TA).
Xuebing Li +5 more
doaj +2 more sources
No improvement in pregnancy and perinatal outcomes with combined luteal support in modified natural cycle frozen embryo transfer [PDF]
ObjectiveWe investigated whether the addition of a luteal phase support drug benefits pregnancy and perinatal outcomes in modified natural-cycle frozen-thawed embryo transfer (mNC-FET) for women up to the age of 35 years.MethodsWe analyzed the clinical ...
Wen Zhang +7 more
doaj +2 more sources
Efficacy of Jia Wei Shoutai Wan Combined With Dydrogesterone in the Treatment of Threatened Abortion Complicated With Endometrial Cavity Fluid: A Prospective, Single-Center, Randomized Controlled Trial. [PDF]
Objective This study aimed to evaluate the clinical efficacy of Jia Wei Shoutai Wan (JWSTW) combined with dydrogesterone in patients with threatened abortion (TA) complicated by endometrial cavity fluid (ECF). Methods This was a prospective, singleācenter, randomized controlled trial.
Zhang Y, Wei H, Li H, Zhang Y, Jia F.
europepmc +2 more sources
Effectiveness of innovator dydrogesterone versus generic dydrogesterone in early pregnancy: a real-world analysis [PDF]
Background: Miscarriage is the most common complication of early pregnancy. Dydrogesterone, a retro-steroid with high oral bioavailability and receptor selectivity, is widely prescribed to support and maintain pregnancy via its novel immunomodulation ...
Govindaraj, Jayanthy +7 more
core +3 more sources
ObjectiveThe need of luteal support after FET is no longer to be proven. Different routes of progesterone administration are available with interindividual differences in metabolization and serum progesterone levels, the latter being highly correlated ...
Virginie Simon +11 more
doaj +1 more source
Background: Despite some progress has been made in the pathogenesis and treatment of threatened miscarriage (TM), conventional treatment remains suboptimal.
Kai Chen +5 more
doaj +1 more source

