Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Exploring perspectives of Scottish medical students on the proposed 'Assisted Dying for Terminally Ill Adults (Scotland)' Bill. [PDF]
BMC Med EthicsGeddes D, Knox J, Obree D, Harden J.
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Critical Care Nurses' Attitude Towards Caring for Dying Patients and Its Relationship With Authenticity in Southeastern Iran: A Descriptive Correlational Study. [PDF]
Health Sci RepAlizadeh A +3 more
europepmc +1 more source
The grammatical puzzles of Socrates' last words [PDF]
Socrates says "we owe" in the last words as head of his οἶκος, a collectivity owing a debt for the recovery from disease of one of Socrates' young sons.
Eisenstadt, Michael
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Medical student's experiences of communication with dying patients and their families. [PDF]
BMC Med EducFrost I, Alberti H, Holdsworth R.
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Exploring the concept of a "friendly relationship to death" in geriatric patients. [PDF]
BMC GeriatrRaboti Z +4 more
europepmc +1 more source