Results 81 to 90 of about 967,120 (307)

The Roles and Responsibilities of Community Pharmacists Supporting Older People with Palliative Care Needs: A Rapid Review of the Literature

Pharmacy, 2020
Globally, the number of older people requiring appropriate and safe management of medicines is growing. This review aimed to identify the roles and responsibilities of pharmacists supporting older people living in a community setting with their ...
Paul Tait, Amal Chakraborty, Jennifer Tieman   +2 more
doaj   +1 more source

Dying well [PDF]

This paper recommends more public discussion, including an education campaign, about the limits of health care as death approaches and the need to focus on end-of-life care. Overview This report is about how, where and with whom we die.
Hal Swerissen, Stephen Duckett
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Physician Assisted Dying: A Turning Point? [PDF]

, 2016
Physician Assisted Dying (PAD) has been lawful in some countries since the 1940s and in the United States since 1997. There is a body of social and scientific research that has focused on whether the practice has been misused and whether gaps exist in ...
Gostin, Lawrence O., Roberts, Anna E.
core   +1 more source

Learning To Be Affected: Social suffering and total pain at life’s borders. [PDF]

, 2012
The practice of Live Sociology in situations of pain and suffering is the author’s focus. An outline of the challenges of understanding pain is followed by a discussion of Bourdieu’s ‘social suffering’ (1999) and the palliative care philosophy of ‘total ...
Ahmed S., Ahmed S., Back L., Badiou A., Bar-On D., Bourdieu P., Brown G., Butler J., Calarco M., DeLanda M., Derrida J., Derrida J., Gordon A., Gunaratnam Y., Hagglund M., Harman G., Keats J., Lawton J., Levinas E., Saunders C. M., Saunders C. M., Saunders C. M., Scarry E., Shields R., Stanworth R., Turner B. S., Waddell M., Weber M., Wyschogrod E., Yasmin Gunaratnam   +29 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Liver Transplantation for Budd-Chiari Syndrome [PDF]

, 1976
Orthotopic liver transplantation was accomplished in a 22-year-old woman dying of the Budd-Chiari syndrome. She is well and has normal liver function 16 months postoperatively.
Porter, KA, Putnam, CW, Reid, HAS, Starzl, TE, Weil, R   +4 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

In Defense of the Ordinary / Extraordinary Distinction [PDF]

, 1978
The author, an assistant professor of philosophy at Emory and Henry College, Emory, Virginia, explains that his paper defends the traditional doctrine against a recent proposal by Robert M.
O\u27Neil, Richard
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source