Results 261 to 270 of about 17,522 (280)
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Reconstitution of Dynein/Dynactin Transport Using Recombinant Dynein.
Methods in molecular biology, 2023Cytoplasmic dynein-1 is activated by dynactin and a cargo adaptor for processive transport along microtubules. Dynein's motility can be visualized at the single-molecule level using total internal reflection fluorescence microscopy. Our understanding of the motile behavior of the dynein/dynactin complex has been aided by advances in recombinant ...
C. K. Lau
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Annual Review of Cell and Developmental Biology, 2004
▪ Abstract Dynactin is a multisubunit protein complex that is required for most, if not all, types of cytoplasmic dynein activity in eukaryotes. Dynactin binds dynein directly and allows the motor to traverse the microtubule lattice over long distances.
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▪ Abstract Dynactin is a multisubunit protein complex that is required for most, if not all, types of cytoplasmic dynein activity in eukaryotes. Dynactin binds dynein directly and allows the motor to traverse the microtubule lattice over long distances.
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ACS Nano
After entering host cells by endocytosis, influenza A virus (IAV) is transported along microfilaments and then transported by dynein along microtubules (MTs) to the perinuclear region for genome release.
Dandan Fu +9 more
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After entering host cells by endocytosis, influenza A virus (IAV) is transported along microfilaments and then transported by dynein along microtubules (MTs) to the perinuclear region for genome release.
Dandan Fu +9 more
semanticscholar +1 more source
Dynactin is essential for growth cone advance
Biochemical and Biophysical Research Communications, 2008Dynactin is a multi-subunit complex that serves as a critical cofactor of the microtubule motor cytoplasmic dynein. We previously identified dynactin in the nerve growth cone. However, the function of dynactin in the growth cone is still unclear. Here we show that dynactin in the growth cone is required for constant forward movement of the growth cone.
Takako K, Abe +6 more
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Diamond controls epithelial polarity through the dynactin‐dynein complex
Traffic, 2023AbstractEpithelial polarity is critical for proper functions of epithelial tissues, tumorigenesis, and metastasis. The evolutionarily conserved transmembrane protein Crumbs (Crb) is a key regulator of epithelial polarity. Both Crb protein and its transcripts are apically localized in epithelial cells.
Hang Zhao +9 more
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Dynactin is involved in Lewy body pathology
Neuropathology, 2018Dynactin forms a protein complex with dynein that retrogradely transports cargo along microtubules. Dysfunction of this dynein‐dynactin complex causes several neurodegenerative diseases such as Perry syndrome, motor neuron diseases and progressive supranuclear palsy.
Chang Shen +8 more
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Microtubule dynamics regulates Akt signaling via dynactin p150
Cellular Signalling, 2014Following activation at the plasma membrane, Akt is subsequently deactivated in the cytoplasm. Although activation and deactivation of Akt must sometimes be separated in order to elicit and control cellular responses, the exact details of the spatiotemporal organization of Akt signaling are incompletely understood.
Jo, Hakryul, Loison, Fabien, Luo, Hongbo
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Cytoplasmic dynein/dynactin mediates the assembly of aggresomes
Cell Motility, 2002AbstractAggresomes are pericentrosomal cytoplasmic structures into which aggregated, ubiquitinated, misfolded proteins are sequestered. Misfolded proteins accumulate in aggresomes when the capacity of the intracellular protein degradation machinery is exceeded.
Jennifer A, Johnston +2 more
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1999
Abstract The dynactin molecule as a unit appears to be unique, though it is structurally similar to the short actin filaments that comprise the erythrocyte membrane cytoskeleton. This has led to speculation that the dynactin Arp1 filament might bind membranes via a spectrin network.
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Abstract The dynactin molecule as a unit appears to be unique, though it is structurally similar to the short actin filaments that comprise the erythrocyte membrane cytoskeleton. This has led to speculation that the dynactin Arp1 filament might bind membranes via a spectrin network.
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Dynactin mutations and promises for neurodegenerative pathology
Clinical Genetics, 2009DCTN1 mutations in Perry syndromeFarrer et al.
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