Results 141 to 150 of about 32,127,622 (336)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Chopped and minibars reinforced high-performance concrete: machine learning prediction of mechanical properties

Frontiers in Built Environment
A novel form of high-tech concrete known basalt fiber-reinforced high-performance concrete (BFHPC) has been developed using traditional materials that require extra admixtures to improve its mechanical properties. Machine learning (ML) techniques provide
Nikolai Ivanovich Vatin, Mohammad Hematibahar, Tesfaldet Hadgembes Gebre   +2 more
doaj   +1 more source

MOD-1 WTG dynamic analysis [PDF]

An analysis of the MOD-1 2000 kW horizontal axis wind turbine was given. The MOD-1 design was briefly described, and the analysis used to evaluate the dynamic loads and structural interactions is discussed. The resonant frequency placement, the treatment
Stahle, C. V., Jr.
core   +1 more source

Beyond Reuse Distance Analysis: Dynamic Analysis for Characterization of Data Locality Potential [PDF]

, 2013
Emerging computer architectures will feature drastically decreased flops/byte (ratio of peak processing rate to memory bandwidth) as highlighted by recent studies on Exascale architectural trends.
Elango, Venmugil, Fauzia, Naznin, Pouchet, Louis-Noël, Ramanujam, J., Rastello, Fabrice, Ravishankar, Mahesh, Rountev, Atanas, Sadayappan, P.   +7 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Climate change and viticulture - a quantitative analysis of a highly dynamic research field

, 2016
Werner Marx, Robin Haunschild, Lutz Bornmann   +2 more
openalex   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A Dynamic Analysis Data Preprocessing Technique for Malicious Code Detection with TF-IDF and Sliding Windows [PDF]

Mihui Kim, Haesoo Kim
openalex   +1 more source

Does replacing coal with wood lower CO ₂ emissions? Dynamic lifecycle analysis of wood bioenergy [PDF]

, 2018
John D. Sterman, Lori Siegel, Juliette N. Rooney‐Varga   +2 more
openalex   +1 more source