Results 31 to 40 of about 28,075 (149)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Enhancement of strength and ductility of cement-based composites by incorporating silica nanoparticle coated polyvinylalcohol fibers

AIP Advances, 2019
Addition of fibers can give brittle material extrinsic toughness, mainly because of the bridging effects. However, such behavior is highly dependent on the interfacial interaction between fiber and brittle matrix.
Jing Meng, Jing Zhong, Huigang Xiao, Jinping Ou   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Numerical Investigations of Snow Load Interference Effects on Multiple Arched Roofs Under Wind–Snow Coupled Actions

Applied Sciences
Driven by the intensification of climate change, extreme snow events are becoming more frequent, posing significant risks to the safety of arched-roof structures. The combination of strong winds and heavy snowfall will cause localized snowdrifts that may
Guolong Zhang, Qingwen Zhang, Huamei Mo, Dong Guo, Xudong Zhi, Feng Fan   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Building with Snow: Technical Exploration and Practice of Snow Materials and Snow Architecture

Buildings
Focusing on the design and construction of snow structures, this paper explores the properties of snow materials, construction methods, and operation–maintenance strategies, aiming to demonstrate how to integrate architectural functionality, aesthetics ...
Jianfeng Sun, Qingwen Zhang, Guolong Zhang, Feng Fan   +3 more
doaj   +1 more source

Effects of Temperature and Stress on Creep Behavior of PP and Hybrid Fiber Reinforced Reactive Powder Concrete

International Journal of Concrete Structures and Materials, 2019
Reactive powder concrete (RPC) is an advanced cementitious material with ultra-high strength, remarkable durability and excellent toughness. However, temperature dependent creep is a major concern as very little work has been reported in the literature ...
Xiaomeng Hou, Muhammad Abid, Wenzhong Zheng, Raja Rizwan Hussain   +3 more
doaj   +1 more source

Stressing State Analysis of Reinforcement Concrete Beams Strengthened with Carbon Fiber Reinforced Plastic

International Journal of Concrete Structures and Materials, 2020
This paper investigated the working behavior characteristics of six reinforcement concrete (RC) beams subjected to bending based on the numerical shape function (NSF) method and structural stressing state theory.
Jie Huang, Jun Shi, Hengheng Xiao, Jiyang Shen, Baisong Yang   +4 more
doaj   +1 more source

Energy-Efficient Retrofitting under Incomplete Information: A Data-Driven Approach and Empirical Study of Sweden

Buildings, 2022
The building performance simulation (BPS) based on physical models is a popular method to estimate the expected energy-savings of energy-efficient building retrofitting.
Kailun Feng, Weizhuo Lu, Yaowu Wang, Qingpeng Man   +3 more
doaj   +1 more source