Results 51 to 60 of about 734,048 (269)

Energy-Efficient Retrofitting under Incomplete Information: A Data-Driven Approach and Empirical Study of Sweden

open access: yesBuildings, 2022
The building performance simulation (BPS) based on physical models is a popular method to estimate the expected energy-savings of energy-efficient building retrofitting.
Kailun Feng   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A Context-Conditioned Reinforcement Learning Framework for Space Frame Structure Optimization

open access: yesBuildings
With the rapid advancement of artificial intelligence in recent years, its adoption in structural design has been increasing. However, supervised learning in engineering design is often limited by the availability and quality of labeled data.
Yinbin Li   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Experiment Investigation and Numerical Simulation of Snowdrift on a Typical Large-Span Retractable Roof

open access: yesComplexity, 2019
Retractable roofs are commonly used in designing large-span stadiums because of their versatility. However, retractable roofs are subject to sudden changes in shape, and thus, factors in addition to those considered for conventional roofs need to be ...
Zhenggang Cao   +2 more
doaj   +1 more source

A dynamic model of timing behavior

open access: yesActa Psychologica, 1967
Abstract Studies of tapping behavior have failed to incorporate the sequential aspects of the performance of subjects. A methodological frame (generating functions) and a model (a dynamic linear system with two parameters) are proposed to improve our descriptive and predictive power.
J A, Michon, N J, van der Valk
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Research on the Dynamic Mechanical Properties and Constitutive Models of Steel Fiber Reinforced Concrete and Polypropylene Fiber Reinforced Concrete

open access: yesAdvances in Civil Engineering, 2020
This paper presents the results of an experimental research designed to investigate the dynamic mechanical properties and constitutive model of fiber reinforced concrete (FRC), including steel fiber reinforced concrete (SFRC) and polypropylene fiber ...
Jie Huang   +6 more
doaj   +1 more source

Precision Teaching and Behavior Dynamics [PDF]

open access: yesBehavior Analysis in Practice, 2020
Precision teaching (PT) comprises a sophisticated measurement and decision-making system aimed at helping its users foster superior outcomes for the clients or students they serve. The longevity of PT has led to many discoveries surrounding measurement, performance, learning, and behavior change.
openaire   +2 more sources

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