Results 151 to 160 of about 1,307,758 (299)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
The divergent transitions towards sustainable biofuel networks/chains [PDF]
In this exploratory paper we investigate how Capabilities, Transaction Costs and Vertical Scope co-evolve, by testing the Jacobides & Winter (2005) model on the Biofuels Industry in the area of the EU. The theoretical framework is based on the Industrial
Karamichas, D., Wubben, E.F.M.
core +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Evidence-based practice dynamic capabilities: a concept derivation and analysis. [PDF]
Ann Transl Med, 2022 Huo M, Zhao B, Li Y, Li J.
europepmc +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
How do firms create business value and dynamic capabilities by leveraging big data analytics management capability? [PDF]
Inf Technol Manag, 2022 Gao J, Sarwar Z.
europepmc +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Entrepreneurship and the National System of Innovation: What is Missing in Turkey? [PDF]
Although very dynamic and flexible, Turkish SMEs are less innovative than their European counterparts. The analysis undertaken in this paper allows to assess whether this low level of innovative activities is related to a lack of entrepreneurial ...
Bascavusoglu-Moreau, Elif
core
A Configurational Analysis of Small and Medium-Sized Enterprises' Radical Innovations: The Perspective of Dynamic Capabilities. [PDF]
Front Psychol, 2021 Tang S, Liao S, Wang L, Chen W, Guo Z.
europepmc +1 more source