Results 11 to 20 of about 3,107,467 (149)
StdpC: A Modern Dynamic Clamp [PDF]
Journal of Neuroscience Methods, 2006 With the advancement of computer technology many novel uses of dynamic clamp have become possible. We have added new features to our dynamic clamp software StdpC ("Spike timing-dependent plasticity Clamp") allowing such new applications while conserving the ease of use and installation of the popular earlier Dynclamp 2/4 package. Here, we introduce the
Attila Szűcs +2 more
exaly +5 more sources
Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing [PDF]
Frontiers in Physiology, 2018 Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in ...
Francis A. Ortega +4 more
doaj +6 more sources
Towards a Dynamic Clamp for Neurochemical Modalities [PDF]
Sensors, 2015 The classic dynamic clamp technique uses a real-time electrical interface between living cells and neural simulations in order to investigate hypotheses about neural function and structure.
Catalina Maria Rivera +8 more
doaj +7 more sources
Single Electrode Dynamic Clamp With StdpC
Journal of Neuroscience Methods, 2012 Dynamic clamp is a powerful approach for electrophysiological investigations allowing researchers to introduce artificial electrical components into target neurons to simulate ionic conductances, chemical or electrotonic inputs or connections to other cells.
Michael Crossley +2 more
exaly +4 more sources
Dynamic clamp with StdpC software [PDF]
Nature Protocols, 2011 Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs. This method is based on a fast cycle of measuring the membrane potential of a cell, calculating the current of a desired simulated component using an appropriate model and injecting ...
Kemenes, Ildikó +6 more
core +5 more sources
High-speed dynamic-clamp interface
Journal of Neurophysiology, 2015 The dynamic-clamp technique is highly useful for mimicking synaptic or voltage-gated conductances. However, its use remains rare in part because there are few systems, and they can be expensive and difficult for less-experienced programmers to implement.
Yang, Yang +4 more
openaire +6 more sources
Causes of Transient Instabilities in the Dynamic Clamp [PDF]
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2009 The dynamic clamp is a widely used method for integrating mathematical models with electrophysiological experiments. This method involves measuring the membrane voltage of a cell, using it to solve computational models of ion channel dynamics in real-time, and injecting the calculated current(s) back into the cell. Limitations of this technique include
Robert J. Butera, Amanda J Preyer
exaly +3 more sources
A dynamic clamp protocol to artificially modify cell capacitance [PDF]
eLife, 2022 Dynamics of excitable cells and networks depend on the membrane time constant, set by membrane resistance and capacitance. Whereas pharmacological and genetic manipulations of ionic conductances of excitable membranes are routine in electrophysiology ...
Paul Pfeiffer +5 more
doaj +2 more sources
Generalization of the dynamic clamp concept in neurophysiology and behavior. [PDF]
PLoS ONE, 2012 The idea of closed-loop interaction in in vitro and in vivo electrophysiology has been successfully implemented in the dynamic clamp concept strongly impacting the research of membrane and synaptic properties of neurons.
Pablo Chamorro +5 more
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Dynamic compression bone clamp for transverse fractures
Plastic Surgery, 2000 A bone clamp with the following important features is described: it provides a dynamic compression force to transversely fractured bone ends before they are fixed with internal hardware; it is designed to reduce transverse bone fractures; and it holds the bone with sharp, opposing points like a towel clip.
Donald H Lalonde
openaire +2 more sources