Results 21 to 30 of about 3,107,467 (149)
eLife, 2022 Reciprocal inhibition is a building block in many sensory and motor circuits. We studied the features that underly robustness in reciprocally inhibitory two neuron circuits.
Ekaterina Morozova +2 more
doaj +1 more source
Frontiers in Pharmacology, 2022 The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated ventricular repolarization and an increased susceptibility to arrhythmia and sudden death.
Chunyun Du +9 more
doaj +1 more source
Circulation: Arrhythmia and Electrophysiology, 2015 Mutations in KCNH2 (hERG) underlie the long-QT2 syndrome. Most long-QT2 mutations produce a trafficking defect resulting in a decrease in n, the number of functional channels on the cell surface. Some mutations can also alter gating characteristics.
Thomas Nowotny, Pablo Varona
openaire +3 more sources
A Dynamic Clamp on Every Rig [PDF]
eneuro, 2017 AbstractThe dynamic clamp should be a standard part of every cellular electrophysiologist’s toolbox. That it is not, even 25 years after its introduction, comes down to three issues: money, the disruption that adding dynamic clamp to an existing electrophysiology rig entails, and the technical prowess required of experimenters.
Niraj S. Desai +2 more
openaire +2 more sources
eLife, 2020 Across biological systems, cooperativity between proteins enables fast actions, supra-linear responses, and long-lasting molecular switches. In the nervous system, however, the function of cooperative interactions between voltage-dependent ionic channels
Paul Pfeiffer +5 more
doaj +1 more source
eLife, 2020 Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in new ...
Marco A Navarro +6 more
doaj +1 more source
Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes [PDF]
, 2012 Background and aim: Human atrial transient outward K+ current (ITO) is decreased in a variety of cardiac pathologies, but how ITO reduction alters action potentials (AP) and arrhythmia mechanisms is poorly understood, owing to non-selectivity of ITO ...
Marshall, G.E. +4 more
core +1 more source
Loading Dynamics of a Sliding DNA Clamp [PDF]
Angewandte Chemie, 2014 AbstractSliding DNA clamps are loaded at a ss/dsDNA junction by a clamp loader that depends on ATP binding for clamp opening. Sequential ATP hydrolysis results in closure of the clamp so that it completely encircles and diffuses on dsDNA. We followed events during loading of an E. coli β clamp in real time by using single‐molecule FRET (smFRET).
Cho, Won-Ki +4 more
openaire +5 more sources
Frontiers in Pharmacology, 2021 Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myocytes.
Arie O. Verkerk +8 more
doaj +1 more source
Frontiers in Physiology, 2012 While the mouse presents an invaluable experimental model organism in biology, its usefulness in cardiac arrhythmia research is limited in some aspects due to major electrophysiological differences between murine and human action potentials (APs).
Corina Teodora Bot +8 more
doaj +1 more source