Results 71 to 80 of about 118,733 (263)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Study on the Dynamic Mechanical Properties of Polypropylene Fiber-Reinforced Concrete Based on a 3D Microscopic Model

Buildings
Polypropylene (PP) fibers, known for their high fracture strength, low density, and cost-effectiveness, can significantly enhance the impact resistance of concrete, making the material suitable for specialized engineering applications.
Shiliang Liu, Zhimin Du, Yanan Wang, Jiawei Wang, Zhibo Dong   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Dynamic Compressed Strings with Random Access [PDF]

, 2013
We consider the problem of storing a string $S$ in dynamic compressed form, while permitting operations directly on the compressed representation of $S$: access a substring of $S$; replace, insert or delete a symbol in $S$; count how many occurrences of a given symbol appear in any given prefix of $S$ (called rank operation) and locate the position of ...
Roberto Grossi, Rajeev Raman, Srinivasa Rao Satti, Rossano Venturini   +3 more
openaire   +4 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

On the Developing Network of Adiabatic Shear Bands During High Strain-Rate Forging Process: A Parametric Study on the Effect of Specimen Aspect Ratio

Engineering Proceedings
The present work studies the developing network of adiabatic shear bands (ASBs) during dynamic plane strain compression of orthogonal AISI 1045 steel billets, aiming to investigate the ASB trajectories and their evolution mechanism. This paper conducts a
Konstantina D. Karantza, Dimitrios E. Manolakos   +1 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Equation of state measurements of boron nitride under laser-driven compression at the Prague Asterix Laser System facility

High Power Laser Science and Engineering
We have investigated the equation of state (EoS) of hexagonal boron nitride (h-BN) under extreme conditions using the Prague Asterix Laser System facility. The experiment employed a 438 nm wavelength laser pulse with a pulse duration of approximately 350
Hanna Marchenko, Agnieszka Zaras-Szydlowska, Dimitri Batani, Donaldi Mancelli, Diluka Singappuli, Yair Ferber, Eran Greenberg, Artem S. Martynenko, Noaz Nissim, Roman Dudzak, Shubham Agarwal, Pooja Devi, David Ettel, Pavel Gajdoš, Simon Jelinek, Michal Krupka, Miroslav Krus, Libor Juha, Sushil Singh, Katarzyna Liliana Batani   +19 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source