Results 1 to 10 of about 22,823 (119)
Effect of recombinant Sox9 protein on the expression of cartilage-specific genes in human dermal fibroblasts cell culture [PDF]
Research Results in Pharmacology, 2022 Introduction: Damage to the hyaline layer of large joints resulting from injuries or age-related changes restricts their mobility. The repair of these disorders is an actual issue in medicine.
Mikhail S. Bozhokin +5 more
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Runx1 is critical for PTH-induced onset of mesenchymal progenitor cell chondrogenic differentiation. [PDF]
PLoS ONE, 2013 Parathyroid hormone (PTH) plays a critical role in the regulation of chondrogenesis. In this study, we have found for the first time that Runt-related transcription factor 1 (Runx1) contributes to PTH-induced chondrogenesis.
Jinwu Wang +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 ObjectiveArticular cartilage of the knee joint is avascular, exists under a low oxygen tension microenvironment, and does not self-heal when injured. Human infrapatellar fat pad-sourced mesenchymal stem cells (IFP-MSC) are an arthroscopically accessible ...
Samia Rahman +8 more
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Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells. [PDF]
PLoS ONE, 2015 While human mesenchymal stem cells (hMSCs), either in the bone marrow or in tumour microenvironment could be targeted by radiotherapy, their response is poorly understood.
Séverine Cruet-Hennequart +7 more
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Comparative Analysis of Cartilage Marker Gene Expression Patterns during Axolotl and Xenopus Limb Regeneration. [PDF]
PLoS ONE, 2015 Axolotls (Ambystoma mexicanum) can completely regenerate lost limbs, whereas Xenopus laevis frogs cannot. During limb regeneration, a blastema is first formed at the amputation plane.
Kazumasa Mitogawa +3 more
doaj +1 more source
Differential effect of frequency and duration of mechanical loading on fetal chick cartilage and bone development [PDF]
European Cells & Materials, 2021 Developmental engineering strategies aim to recapitulate aspects of development in vitro as a means of forming functional engineered tissues, including cartilage and bone, for tissue repair and regeneration.
N Khatib, C Parisi, NC Nowlan
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npj Regenerative Medicine, 2022 Osteoarthritis (OA) is the leading cause of disability worldwide. Considerable progress has been made using stem-cell-derived therapy. Increasing evidence has demonstrated that the therapeutic effects of BMSCs in chondrogenesis could be attributed to the
Ye Sun +6 more
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iScience, 2023 Summary: Human mesenchymal stem cells (MSCs) remain one of the best cell sources for cartilage, a tissue without regenerative capacity. However, MSC chondrogenesis is commonly induced through TGFβ, a pleomorphic growth factor without specificity for this
Chen-Chan Hsieh +7 more
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A new era of genetic diagnosis for short stature children: A review [PDF]
Precision and Future Medicine, 2022 Children with short stature are often presented to pediatric endocrinologists. Short stature is defined as the height that is more than two standard deviations below the corresponding mean height for a specific age and sex in a reference population ...
Yoo-Mi Kim
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Frontiers in Pharmacology, 2020 Mesenchymal stem cell (MSC)–based articular regeneration might be beneficial for both protecting and rebuilding cartilaginous tissues in the management of rheumatoid arthritis. However, it is unclear how current immunosuppressive strategies influence the
Shuang Liu +3 more
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