Results 11 to 20 of about 22,928 (224)
Mechanical regulation of chondrogenesis [PDF]
Stem Cell Research & Therapy, 2013 Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell-based cartilage repair strategies. However, a thorough understanding of how individual mechanical factors influence stem cell fate is needed ...
O'Conor, Christopher J +2 more
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The role of Nkx3.2 in chondrogenesis [PDF]
Frontiers in Biology, 2014 Transcription factor, Nkx3.2, is a member of the NK family of developmental genes and is expressed during embryogenesis in a variety of mammalian model organisms, including chicken and mouse. It was first identified in Drosophila as the Bagpipe (bap) gene, where it has been demonstrated to be essential during formation of the midgut musculature ...
Roshni S, Rainbow +2 more
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miR-892b Inhibits Hypertrophy by Targeting KLF10 in the Chondrogenesis of Mesenchymal Stem Cells
Molecular Therapy: Nucleic Acids, 2019 We investigated the functional role of miR-892b as a novel inhibitor of chondrocyte hypertrophy during TGF-β-mediated chondrogenesis of human mesenchymal stem cells (hMSCs). The expression of miR-892b during TGF-β-mediated chondrogenesis of hMSCs and the
Jong Min Lee +5 more
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Evaluation of metabolomic changes as a biomarker of chondrogenic differentiation in 3D-cultured human mesenchymal stem cells using proton (1H) nuclear magnetic resonance spectroscopy. [PDF]
PLoS ONE, 2013 PURPOSE:The purpose of this study was to evaluate the metabolomic changes in 3D-cultured human mesenchymal stem cells (hMSCs) in alginate beads, so as to identify biomarkers during chondrogenesis using (1)H nuclear magnetic resonance (NMR) spectroscopy ...
Moo-Young Jang +4 more
doaj +1 more source
Protocol for efficient human MSC chondrogenesis via Wnt antagonism instead of TGF-β
STAR Protocols, 2023 Summary: To better implement mesenchymal stem cell (MSC)-based therapy toward cartilage diseases, a more efficient and less off-target chondrogenesis protocol is needed.
Chen-Chan Hsieh +4 more
doaj +1 more source
The Janus Role of Adhesion in Chondrogenesis [PDF]
International Journal of Molecular Sciences, 2020 Tackling the first stages of the chondrogenic commitment is essential to drive chondrogenic differentiation to healthy hyaline cartilage and minimize hypertrophy. During chondrogenesis, the extracellular matrix continuously evolves, adapting to the tissue adhesive requirements at each stage. Here, we take advantage of previously developed nanopatterns,
Ignasi Casanellas +6 more
openaire +4 more sources
Stem Cell Research & Therapy, 2017 Background Mesenchymal stem cells (MSCs) hold great promise for cartilage repair given their relative abundance, ease of isolation, and chondrogenic potential.
Tianyi Wang, Fan Yang
doaj +1 more source
PLoS ONE, 2013 Many cartilage tissue engineering approaches aim to differentiate human mesenchymal stem cells (hMSCs) into chondrocytes and develop cartilage in vitro by targeting cell-matrix interactions.
Vanessa L S LaPointe +2 more
doaj +1 more source
Molecules, 2020 Several plant polyphenols have been shown to reduce osteoarthritis symptoms due to their antioxidant, anti-inflammatory and immunomodulatory properties.
Mateja Sirše +3 more
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BMC Cardiovascular Disorders, 2023 Background Induction of chondrogenesis is associated with progressive atherosclerosis. Deficiency of the ADCYAP1 gene encoding pituitary adenylate cyclase-activating peptide (PACAP) aggravates atherosclerosis in ApoE deficient (ApoE−/−) mice.
C. Blümm +5 more
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