Results 21 to 30 of about 22,928 (224)
Enhancing chondrogenic potential via mesenchymal stem cell sheet multilayering
Regenerative Therapy, 2021 Advanced tissue engineering approaches for direct articular cartilage replacement in vivo employ mesenchymal stem cell (MSC) sources, exploiting innate chondrogenic potential to fabricate hyaline-like constructs in vitro within three-dimensional (3D ...
Hallie Thorp +6 more
doaj +1 more source
Vinculin Functions as Regulator of Chondrogenesis [PDF]
Journal of Biological Chemistry, 2012 To identify the genes involved in chondrocytic differentiation, we applied gene trap mutagenesis to a murine mesenchymal chondrogenic cell line ATDC5 and isolated a clone in which the gene encoding vinculin was trapped. The trapped allele was assumed to express a fusion protein containing a truncated vinculin lacking the tail domain and the geo product
Takao, Koshimizu +6 more
openaire +2 more sources
Pharmaceuticals, 2022 Tissue engineering and regenerative medicine (TERM) have paved a way for treating musculoskeletal diseases in a minimally invasive manner. The regenerative medicine cocktail involves the usage of mesenchymal stem/stromal cells (MSCs), either uncultured ...
Gollahalli Shivashankar Prajwal +12 more
doaj +1 more source
Sox9-regulated miRNA-574-3p inhibits chondrogenic differentiation of mesenchymal stem cells. [PDF]
PLoS ONE, 2013 The aim of this study was to identify new microRNAs (miRNAs) that are modulated during the differentiation of mesenchymal stem cells (MSCs) toward chondrocytes.
David Guérit +7 more
doaj +1 more source
Revista Brasileira de Ortopedia, 2021 Objective To evaluate clinically and radiologically the results of the treatment of chondral lesions using collagen membrane - autologous matrix-induced chondrogenesis (AMIC).
Mateus Kenji Christo Miyahira +5 more
doaj +2 more sources
Cells under pressure – the relationship between hydrostatic pressure and mesenchymal stem cell chondrogenesis [PDF]
European Cells & Materials, 2019 Early osteoarthritis (OA), characterised by cartilage defects, is a degenerative disease that greatly affects the adult population. Cell-based tissue engineering methods are being explored as a solution for the treatment of these chondral defects ...
G Pattappa +4 more
doaj +1 more source
Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: Influence of microenvironment, tissue origin and growth factor [PDF]
European Cells & Materials, 2011 nchymal stromal cells (MSCs), which reside within various tissues, are utilized in the engineering of cartilage tissue. Dexamethasone (DEX) – a synthetic glucocorticoid – is almost invariably applied to potentiate the growth-factor-induced chondrogenesis
N Shintani, EB Hunziker
doaj
Frontiers in Pharmacology, 2021 Objectives: Zeel T (Ze14) is a multicomponent medicinal product. Initial preclinical data suggested a preventive effect on cartilage degradation. Clinical observational studies demonstrated that Ze14 reduced symptoms of osteoarthritis (OA), including ...
Christelle Sanchez +9 more
doaj +1 more source
Platelet-rich plasma application in chondrogenesis
Advanced Biomedical Research, 2014 Platelet-rich plasma (PRP), an autologous derivative of whole blood, has been recently used in surgical treatment. PRP contains growth factors including transforming growth factor-β (TGF-β), insulin-like growth factor (IGF), platelet-derived growth ...
Azadeh Kabiri +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mechanisms of WNT and bone morphogenetic protein (BMP) signaling crosstalk is in the focus of multiple biological studies, and it also has been discovered to play important roles in human mesenchymal stromal cells (MSC) that are of great interest for ...
Svitlana Melnik +4 more
doaj +1 more source