Results 31 to 40 of about 22,928 (224)
Retinoid Agonists in the Targeting of Heterotopic Ossification
Cells, 2021 Retinoids are metabolic derivatives of vitamin A and regulate the function of many tissues and organs both prenatally and postnatally. Active retinoids, such as all trans-retinoic acid, are produced in the cytoplasm and then interact with nuclear ...
Robert J. Pignolo, Maurizio Pacifici
doaj +1 more source
The Journal of Cell Biology, 1973 Light and electron microscopy are used in this study to compare chondrogenesis in cultured somites with vertebral chondrogenesis These studies have also characterized some of the effects of inducer tissues (notochord and spinal cord), and different nutrient media, on chondrogenesis in cultured somites Somites from stage 17 (54–60 h) chick embryos were ...
openaire +1 more source
Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis
eLifeChanges in chondrocyte gene expression can contribute to the development of osteoarthritis (OA), and so recognition of the regulative processes during chondrogenesis can lead to a better understanding of OA.
Krutik Patel +7 more
doaj +1 more source
Biomedicines, 2021 Directing adipose-derived stem cells (ADSCs) toward chondrogenesis is critical for ADSC-based articular cartilage regeneration. Simvastatin (SIM) was reported to promote both chondrogenic and osteogenic differentiation of ADSCs by upregulating bone ...
Shun-Cheng Wu +8 more
doaj +1 more source
Epigenetic regulation in chondrogenesis.
Acta medica Okayama, 2010 Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure.
Furumatsu, Takayuki, Ozaki, Toshifumi
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
Journal of Inflammation, 2018 Background Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair.
Shipeng Xiao +8 more
doaj +1 more source
Biology, 2021 Amorphous calcium phosphate (aCaP) nanoparticles may trigger the osteogenic commitment of adipose-derived stem cells (ASCs) in vitro. The ASCs of three human donors are investigated using basal culture medium DMEM to either 5 or 50 µg/mL aCaP ...
Petra Wolint +7 more
doaj +1 more source
Advanced Materials Interfaces, EarlyView.Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung +6 more
wiley +1 more source
Genes and Diseases, 2017 Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes.
Chen Zhao +17 more
doaj +1 more source