Results 51 to 60 of about 22,928 (224)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Designing Tissue Function Through Embedded Bioprinting Architectures

Advanced Science, EarlyView.
Embedded bioprinting enables soft, cell‐dense constructs to be fabricated within supporting bath environments. This review introduces a function‐guided framework linking target tissue functions to architectural requirements, supporting bath selection, bioink design, printing dynamics, and validation assays.
Qi Li, Yifei Cao, Jiaxin Lin, Huayong Yang, Hongzhao Zhou   +4 more
wiley   +1 more source

Type II Collagen Sponges Facilitate Tendon Stem/Progenitor Cells to Adopt More Chondrogenic Phenotypes and Promote the Regeneration of Fibrocartilage-Like Tissues in a Rabbit Partial Patellectomy Model

Frontiers in Cell and Developmental Biology, 2021
ObjectiveFibrocartilage transition zone (FC) is difficult to regenerate after surgical re-attachment of tendon to bone. Here, we investigated whether type II collagen-sponges (CII-sponges) facilitated tendon stem/progenitor cells (TSPCs) to adopt ...
Wen Wang, Wen Wang, Shengnan Qin, Peiliang He, Peiliang He, Wei Mao, Wei Mao, Liang Chen, Liang Chen, Xing Hua, Jinli Zhang, Xifeng Xiong, Zhihe Liu, Pengzhen Wang, Qingqi Meng, Fei Dong, Aiguo Li, Aiguo Li, Honghui Chen, Jiake Xu   +19 more
doaj   +1 more source

SOX6 is expressed in various cell lineages in the developing mouse heart and contributes to proper valvuloseptal development

The Anatomical Record, EarlyView.
Abstract Cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field play a critical role in the formation of the valvuloseptal structures of the heart. Previous studies have shown that the expression of the transcription factor SOX9 in these cell populations is essential in the regulation of this process.
Hannah G. Tarolli, Andrew B. Harvey, Inara Devji, Raymond N. Deepe, Jenna R. Drummond, Renélyn A. Wolters, Andy Wessels   +6 more
wiley   +1 more source

Hyaluronan promotes TRPV4-induced chondrogenesis in ATDC5 cells.

PLoS ONE, 2019
Hyaluronan (HA) is an extracellular matrix glycosaminoglycan essential for the homeostasis of cartilage-related tissues. Intracellular adhesion molecule-1 (ICAM-1) and CD44 have been identified as receptors for HA.
Yoshikazu Ogawa, Nobunori Takahashi, Toki Takemoto, Tsuyoshi Nishiume, Mochihito Suzuki, Naoki Ishiguro, Toshihisa Kojima   +6 more
doaj   +1 more source

Editorial Commentary: It's Not a Matter of “If,” but “When”: Tissue Printing in Orthopaedic Sports Medicine Is Around the Corner

Arthroscopy, EarlyView.
Abstract The treatment of acetabular labral pathology has evolved from selective debridement toward preservation, repair, and reconstruction as the biomechanical importance of the labrum has become increasingly recognized. Despite encouraging clinical outcomes, current autograft and allograft reconstruction techniques remain inherently limited, largely
Philip J. Rosinsky
wiley   +1 more source

The function of mechanical loading on chondrogenesis

Frontiers in Bioscience, 2016
Articular cartilage is exquisitely sensitive to mechanical loading, one of the most important external factors that regulates its development, integrity and long-term maintenance. Cartilage undergoes degradation by its misuse or overuse. In this review, we elaborate on this role and discuss the application of mechanical stress on chondrocytes and ...
Zhe, Chen, Fuhua, Yan, Yong, Lu
openaire   +2 more sources

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Roles of microRNAs in prenatal chondrogenesis, postnatal chondrogenesis and cartilage‐related diseases [PDF]

Journal of Cellular and Molecular Medicine, 2013
AbstractCartilage has limited repair and regeneration capacity, thus damage of cartilage often results in its dysfunction and even chronic diseases like osteoarthritis (OA). Chondrogenesis induced by tissue‐engineering methods is essential to treating cartilage‐related diseases.
Shang, Jin, Liu, Huan, Zhou, Yue
openaire   +2 more sources

Dual‐Scaffold Technique: Autologous Minced Cartilage and Bone Marrow Aspirate Scaffold Combined With Synthetic Collagen Membrane for Cartilage Repair

Arthroscopy Techniques, EarlyView.
Abstract Treating cartilage injuries has long been a complex challenge; however, recent progress has greatly increased the variety of effective therapeutic approaches. The minced autologous matrix‐induced chondrogenesis plus procedure for full‐thickness knee cartilage lesions uses a collagen matrix combined with shaver‐minced cartilage graft and bone ...
Leonardo Ataíde, Moises Cohen, Pedro Debieux, Camila Cohen Kaleka, José Martins Juliano Eustáquio, Lucas Barbosa   +5 more
wiley   +1 more source