Results 61 to 70 of about 22,928 (224)

METTL14 regulates chondrogenesis through the GDF5–RUNX–extracellular matrix gene axis during limb development

Nature Communications
m6A RNA methylation is essential for many aspects of mammalian development but its roles in chondrogenesis remain largely unknown. Here, we show that m6A is necessary for chondrogenesis and limb morphogenesis using limb progenitor-specific knockout mice ...
Nobuko Katoku-Kikyo, Hiroko Kawakami, Max Cantor, Yasuhiko Kawakami, Nobuaki Kikyo   +4 more
doaj   +1 more source

Calcineurin and NFAT4 Induce Chondrogenesis [PDF]

Journal of Biological Chemistry, 2002
Nuclear factor of activated T-cells (NFAT) and calcineurin are essential regulators of immune cell and mesenchymal cell differentiation. Here we show that elevated intracellular calcium induces chondrogenesis through a calcineurin/NFAT signaling axis that activates bone morphogenetic protein (BMP) expression.
Masuhiro, Tomita, Martina I, Reinhold, Jeffery D, Molkentin, Michael C, Naski   +3 more
openaire   +2 more sources

Arthroscopic Treatment of Focal Chondral Defects in the Hip Joint With Autologous Minced Cartilage, Allograft Cartilage Extracellular Matrix, and Platelet‐Rich Plasma

Arthroscopy Techniques, EarlyView.
Abstract Focal chondral defects (FCDs) are often encountered during hip arthroscopy for the treatment of femoroacetabular impingement. Historically, arthroscopic treatment for FCDs in the hip joint has revolved around microfracture, though recent evidence has showed inferior outcomes with this approach. Open cartilage repair procedures in the hip joint
Austin G. Cross, Ashley D. Price, Anthony J. Scillia, Matthew J. Kraeutler   +3 more
wiley   +1 more source

The Effect of Biomolecular Gradients on Mesenchymal Stem Cell Chondrogenesis under Shear Stress

Micromachines, 2015
Tissue engineering is viewed as a promising option for long-term repair of cartilage lesions, but current engineered cartilage constructs fail to match the mechanical properties of native tissue.
Alexander L. Rivera, Harihara Baskaran
doaj   +1 more source

New Insights on Mechanical Stimulation of Mesenchymal Stem Cells for Cartilage Regeneration

Applied Sciences, 2020
Successful tissue regeneration therapies require further understanding of the environment in which the cells are destined to be set. The aim is to structure approaches that aspire to a holistic view of biological systems and to scientific reliability ...
Silvia Ravalli, Marta Anna Szychlinska, Giovanni Lauretta, Giuseppe Musumeci   +3 more
doaj   +1 more source

Treatment of Developmental Dysplasia of the Acetabulum by Hip Arthroscopic Acetabuloplasty Combined With Labral Repair, Cam and Pincer Osteoplasty, Collagen‐Induced Autologous Chondroplasty, and Capsule Suture

Arthroscopy Techniques, EarlyView.
Abstract Developmental hip dysplasia due to insufficient acetabular coverage and excessive pressure on the femoral head can easily lead to labral tears, damage to the labrum–cartilage junction, cam and pincer deformities, and joint capsule laxity. This may ultimately result in osteoarthritis.
Dongdong Zhou, Jin Zhang, Zhe Xue, Zhengwei Zhu, Shihao Yang, Deding Liu, Xinyue Zhang, Ceyong Sun   +7 more
wiley   +1 more source

Increased water temperature contributes to a chondrogenesis response in the eyes of spotted wolffish

Scientific Reports
Adult vertebrate cartilage is usually quiescent. Some vertebrates possess ocular scleral skeletons composed of cartilage or bone. The morphological characteristics of the spotted wolffish (Anarhichas minor) scleral skeleton have not been described.
Rebecca R. Kwabiah, Eva Weiland, Sarah Henderson, Ignacio Vasquez, Hélène Paradis, Denise Tucker, Iliana Dimitrov, Danielle Gardiner, Stephanie Tucker, Nicholas Newhook, Danny Boyce, Giuseppe Scapigliati, Simon Kirby, Javier Santander, Robert L. Gendron   +14 more
doaj   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source

The Effect of BMP-6 Growth Factor on Differentiation of Adipose-derived Stem Cells into Chondrocyte in Pellet Culture System

مجله دانشکده پزشکی اصفهان, 2009
Background:Cartilage damaged by trauma or degenerative arthritis has a limited capacity for regeneration most likely because of its avascularity and low cellularity.
Batool Hashemibeni, Shahnaz Razavi, Ebrahim Esfandiary, Mansour Salehi, Saeed Karbasi, Mohammad Mardani, Fateme Nadali, Farzaneh Sadeghi, Abdolreza Sabahi, Fatemeh Amuzegar, Vida Homayuni   +10 more
doaj