Results 81 to 90 of about 23,621 (212)

GelMA‐Based Hydrogel Encapsulating Astragalus Polysaccharides and Umbilical Cord Mesenchymal Stem Cell Exosomes Promotes Full‐Thickness Skin Wound Healing

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Wound healing involves excessive oxidative stress and cellular dysfunction, while current single therapies remain inadequate. Astragalus polysaccharides (APS) and exosomes (Exos) possess antioxidative and regenerative properties, and gelatin methacryloyl (GelMA) hydrogel provides a biocompatible platform for localized delivery. Here,
Jingwen Tian, Xiangjing Zhao, Jingxian Xie, Zheng Huang, Pengbo Song, Suzhuang Hong, Cailing Tong, Zhongquan Qi   +7 more
wiley   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

PRDM16 is necessary for sensory neuronal development and differentiation in the trigeminal ganglion

Developmental Dynamics, EarlyView.
Abstract Background Cranial neural crest cells (cNCC) generate craniofacial cartilage, bone, and peripheral neurons and glia, and birth defects arise when the cartilage/neuronal/glial progenitors fail to differentiate. PRDM16 is a transcriptional regulator containing both zinc‐finger and SET domains, implicated in craniofacial development and orofacial
Fahmida Raha, Qiman Gao, Lomeli C. Shull, Kristin B. Artinger   +3 more
wiley   +1 more source

Deer antler reserve mesenchyme cells modified with miR-145 promote chondrogenesis in cartilage regeneration

Frontiers in Veterinary Science
Deer antler-derived reserve mesenchyme cells (RMCs) are a promising source of cells for cartilage regeneration therapy due to their chondrogenic differentiation potential. However, the regulatory mechanism has not yet been elucidated.
Boyin Jia, Boyin Jia, Xintong Han, Xin Li, Linlin Zhang, Fuquan Ma, Yusu Wang, Xue Wang, Yaru Yan, Yaxin Li, Junnan Shen, Xinran Chen, Xinyi Li, Qianzhen Zhang, Pengfei Hu, Rui Du, Rui Du   +16 more
doaj   +1 more source

Cartilage Tissue Engineering Via Icariin and Adipose-derived Stem Cells in Fibrin Scaffold

Advanced Biomedical Research, 2018
Background: Nowadays, cartilage tissue engineering is the best candidate for regeneration of cartilage defects. This study evaluates the function of herbal extracts icariin (ICA), the major pharmacological constituent of herba Epimedium, compared with ...
Maryam Bahrami, Ali Valiani, Noushin Amirpour, Mohammad Zamani Ra Rani, Batool Hashemibeni   +4 more
doaj   +1 more source

Hydrogel‐Based Bioelectronics: From Therapy and Sensing to Neuromorphic Computation

FlexTech, EarlyView.
This review establishes a material–conduction–property–application framework connecting hydrogel chemistry and charge transport with therapy, sensing, closed‐loop feedback, and neuromorphic computation. ABSTRACT Bioelectronics establish bidirectional communication between living systems and electronic devices, providing an enabling platform for ...
Jianlong Hong, Jiaqi Lu, Yijun Hao, Ning Ren, Shuhan He, Haobo Qi, Jingfeng Xu, Chengkuo Lee   +7 more
wiley   +1 more source

FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage

Open Medicine
Nasal septal cartilages (NSCs) and mandibular condyle cartilages (MCCs) are two important cartilages for craniomaxillofacial development. However, the role of FLRT2 in the formation of NSCs and MCCs remains undiscovered.
Xie Tao, Zhu Fangyong, Cheng Renyi, Gao Jing, Hong Yuchen, Deng Peishen, Liu Chaofeng, Xu Yanhua   +7 more
doaj   +1 more source

Minced cartilage implantation provides comparable outcomes to autologous chondrocyte implantation (ACI) for knee cartilage lesions: A matched‐pair analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare short‐term patient‐reported outcomes (PROMs) and revision rates between autologous hand‐minced cartilage implantation (MCI) and autologous chondrocyte implantation (ACI) for knee cartilage lesions. Methods All patients undergoing MCI or ACI at a single centre were retrospectively analysed from a prospectively maintained ...
Armin Runer, Louis Leuthard, Luisa Hoheisel, Vincent A. Stadelmann, Stefan Preiss, Gian M. Salzmann, Jakob Hax   +6 more
wiley   +1 more source

Rescued Chondrogenesis of Mesenchymal Stem Cells under Interleukin 1 Challenge by Foamyviral Interleukin 1 Receptor Antagonist Gene Transfer

Frontiers in Pharmacology, 2017
Background: Mesenchymal stem cells (MSCs) and their chondrogenic differentiation have been extensively investigated in vitro as MSCs provide an attractive source besides chondrocytes for cartilage repair therapies.
Nicole Armbruster, Nicole Armbruster, Jennifer Krieg, Jennifer Krieg, Manuel Weißenberger, Carsten Scheller, Andre F. Steinert   +6 more
doaj   +1 more source