Results 121 to 130 of about 120,010 (352)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Dynamic Differential Current-based Transformer Protection Using a Convolutional Neural Network

CSEE Journal of Power and Energy Systems
A reliable transformer protection method is crucial for power systems. Aiming at improving the generalization performance and response speed of multi-feature fusion based transformer protection, this paper presents a dynamic differential current by ...
Zongbo Li, Zaibin Jiao, Anyang He
doaj   +1 more source

Dynamic stall control by passive disturbance generators

, 2011
Passive low-aspect ratio cylinders mounted near the leading edge of an airfoil have been found to significantly improve the performance under dynamic stall conditions.
Joubert, Gilles, Markus Raffel, Benjamin Heine, Gilles Joubert, Raffel, Markus, Heine, Benjamin, Karen Mulleners, Mulleners, Karen   +7 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

LINEAR FREQUENCY DOMAIN PREDICTIONS OF DYNAMIC DERIVATIVES FOR THE DLR F12 WIND TUNNEL MODEL

, 2012
Structural loads for full aircraft configurations can be represented by evaluating dynamic derivatives over a wide parameter space mainly including different mode shapes, an- gle of attack and Mach numbers.
Hübner, Andreas R., Thormann, Reik, Widhalm, Markus   +2 more
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Analysis of Strength Effects on the Dynamic Response of a Shaped-Charge Under Lateral Disturbances

Applied Sciences
To study the variation law of the penetration power of energy-concentrated jets on target plates with different yield strengths under lateral disturbance, a finite element model of the dynamic penetration of energy-concentrated jets was established ...
Xuepeng Zhang, Can Xu, Jianya Yi, Xudong Li, Jianping Yin   +4 more
doaj   +1 more source

Non-linear disturbance observer-based adaptive composite anti-disturbance control for non-linear systems with dynamic non-harmonic multisource disturbances

, 2017
In this paper, an adaptive composite anti-disturbance control structure is constructed for a class of non-linear systems with dynamic non-harmonic multisource disturbances.
Zheng Wang, Jianping Yuan
core   +1 more source

Variable Structure Disturbance Observer Based Dynamic Surface Control of Electrohydraulic Systems with Parametric Uncertainty [PDF]

, 2022
Shuai Li, Ke Zhu, Liang Chen, Yao Yan, Qing Guo   +4 more
openalex   +1 more source