Results 111 to 120 of about 504,506 (305)
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Analysis of Strength Effects on the Dynamic Response of a Shaped-Charge Under Lateral Disturbances
Applied SciencesTo study the variation law of the penetration power of energy-concentrated jets on target plates with different yield strengths under lateral disturbance, a finite element model of the dynamic penetration of energy-concentrated jets was established ...
Xuepeng Zhang +4 more
doaj +1 more source
On-orbit structural dynamic performance of a 15-meter microwave radiometer antenna [PDF]
The on-orbit structural dynamic performance of a microwave radiometer antenna for Earth science applications is addressed. The radiometer is one of the Earth-observing instruments aboard a proposed geostationary platform as part of the Mission to the ...
Farmer, Jeffery T. +2 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Inflation and Globalisation: A Dynamic Factor Model with Stochastic Volatility [PDF]
National inflation rates reflect domestic and international (regional and global) influences. The relative importance of these components remains a controversial empirical issue.
Alexandros Kontonikas +2 more
core
The disturbance model in model based predictive control [PDF]
, 2003 Model Based Predictive Control (MBPC) is a control methodology which uses a process model on-line in the control computer; this model is used for calculating output predictions and optimizing control actions.
De Keyser, Robain +1 more
core +2 more sources
Equivalence of robust stabilization and robust performance via feedback
, 2008 One approach to robust control for linear plants with structured uncertainty as well as for linear parameter-varying (LPV) plants (where the controller has on-line access to the varying plant parameters) is through linear-fractional-transformation (LFT ...
Ball, J. A. +3 more
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source