Results 51 to 60 of about 504,506 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Finite-Time Dynamic Tracking Control of Parallel Robots with Uncertainties and Input Saturation

Sensors, 2021
This paper considers the finite-time dynamic tracking control for parallel robots with uncertainties and input saturation via a finite-time nonsingular terminal sliding mode control scheme.
Mengyang Ye, Guoqin Gao, Junwen Zhong, Qiuyue Qin   +3 more
doaj   +1 more source

Control of multiscale systems with constraints. 1. Basic principles of the concept of evolution of systems with varying constraints [PDF]

, 2012
Physical fundamentals of the self-organizing theory for the system with varying constraints are considered. A variation principle, specifically the principle of dynamic harmonization as a generalization of the Gauss-Hertz principle for the systems with ...
Adamenko, S., Bolotov, V., Novikov, V.
core   +1 more source

Disturbance Propagation in Dynamical Networks

, 2022
First, we consider the input-output analysis of a discrete-time linear network synchronization model using graph-theoretical analysis. We demonstrate that some input-output metrics, including lp gains, frequency responses, frequency-band energy, and Markov parameters, show a spatial decrescence property in which they are nonincreasing along separating ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mechanical response of structural rock slope under cyclic dynamic disturbance

Meikuang Anquan
In order to study the stability of slopes containing weakly inter bedded rocks under dynamic disturbance, the dynamic response characteristics of rocks with different inclinations under dynamic cyclic disturbance are investigated through indoor ...
Zhouai ZHANG, Yongjiang YU, Yongjun WANG
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Experimental Study on Instability Mechanism of Red Shale Roadway Under Dynamic Disturbance

Energy Science & Engineering
To delve into the instability mechanism of the surrounding rock in red shale roadways, a bespoke device was chosen to fabricate a physical model, and a similar experiment was conducted with a blasting‐induced disturbance.
Xuewu Wu, Zhenqian Ma, Jinlian Zhou, Chunhng Mao, Jimin Zhang   +4 more
doaj   +1 more source

Robust model predictive kinematic tracking control with terminal region for wheeled robotic systems

Automatika, 2021
This paper addresses the nonlinear model predictive control (MPC) for wheeled mobile robots (WMRs) under external disturbance. The decoupling technique is utilized based on the non-holonomic constraint description for separating the WMR model.
Phuong Nam Dao, Hong Quang Nguyen
doaj   +1 more source