Results 61 to 70 of about 103,131 (263)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
AERODYNAMIC DISTURBANCE ON VEHICLE’S DYNAMIC PARAMETERS [PDF]
Journal of Engineering Science and Technology, 2018 This research paper analysed the influence of aerodynamic disturbance on vehicle’s dynamic parameters. The vehicle dynamics were formulated from the Newton’s Second Law for modelling the vehicle.
MU’AZU J. MUSA +2 more
doaj
Sensors, 2018 The high-precision speed control of gimbal servo systems is the key to generating high-precision torque for control moment gyroscopes (CMGs) in spacecrafts.
Liya Huang, Zhong Wu, Kan Wang
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Disturbance Propagation in Dynamical Networks
, 2022 First, we consider the input-output analysis of a discrete-time linear network synchronization model using graph-theoretical analysis. We demonstrate that some input-output metrics, including lp gains, frequency responses, frequency-band energy, and Markov parameters, show a spatial decrescence property in which they are nonincreasing along separating ...
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Frontiers in MaterialsThe surrounding rocks in deep roadways frequently undergo dynamic disturbances caused by adjacent blasting or mining activities. These dynamic disturbances lead to the propagation and coalescence of cracks in the surrounding rock, inducing dynamic ...
Tao Zhang +5 more
doaj +1 more source
Dynamic Shear Strength of Rock Joints and Its Influence on Key Blocks
Geofluids, 2019 Shear strength deterioration of rock joints and its induced instability of key blocks subjected to dynamic disturbance constitute the mechanism of many geological disasters such as rockburst, landslide, and rockfall.
Shuhong Wang, Feili Wang, Zhanguo Xiu
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source