Results 81 to 90 of about 103,131 (263)

Experimental Study on the Dynamics of the “Fracture–Migration” Effect in Overburden Under Dynamic Disturbance

Applied Sciences
To investigate overburden movement and three-zone development under far-field strong dynamic disturbance induced by instability of typical thick and hard overburden in western mining areas, a large-scale two-dimensional physical similarity simulation was
Haidong Xu, Chenghong Wu, Xingping Lai, Jiantao Cao, Zhiwei Zheng, Chunyu Ji   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Fracturing mechanism of pre-damaged granite induced by multi-source dynamic disturbances in tunnels

International Journal of Mining Science and Technology
To elucidate the fracturing mechanism of deep hard rock under complex disturbance environments, this study investigates the dynamic failure behavior of pre-damaged granite subjected to multi-source dynamic disturbances.
Biao Wang, Benguo He, Xiating Feng, Hongpu Li   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Analysis of Strength Effects on the Dynamic Response of a Shaped-Charge Under Lateral Disturbances

Applied Sciences
To study the variation law of the penetration power of energy-concentrated jets on target plates with different yield strengths under lateral disturbance, a finite element model of the dynamic penetration of energy-concentrated jets was established ...
Xuepeng Zhang, Can Xu, Jianya Yi, Xudong Li, Jianping Yin   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Generalized High-Order LADRC Tracking Control for VICTS Hollow Annular Direct-Drive Motor Considering Non-Stationary Disturbances

Actuators
This paper proposes a generalized high-order linear active disturbance rejection control (GHO-LADRC) method to suppress non-stationary disturbances in VICTS antenna direct-drive motors during high-dynamic scanning.
Xinlu Yu, Jiacheng Lu, Ping Gao, Pingfa Feng, Lin Jia   +4 more
doaj   +1 more source