Results 101 to 110 of about 3,597,207 (294)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Multi-Peak Narrowband Perfect Absorber Based on the Strong Coupling Between Fabry–Perot Mode and SPP Waveguide Mode

Photonics
Plasmonic- or metamaterial-based multi-narrowband perfect absorbers hold significant potential applications in filtering, photodetection, and spectroscopic sensing.
Yusheng Zhai, Weiji He, Qian Chen
doaj   +1 more source

Bayesian Analysis of the Glacial‐Interglacial Methane Increase Constrained by Stable Isotopes and Earth System Modeling

Geophysical Research Letters, 2018
The observed rise in atmospheric methane (CH4) from 375 ppbv during the Last Glacial Maximum (LGM: 21,000 years ago) to 680 ppbv during the late preindustrial era is not well understood.
Peter O. Hopcroft, Paul J. Valdes, Jed O. Kaplan   +2 more
doaj   +1 more source

Discontinuity in the Environment, Firm Response and Dynamic Capabilities [PDF]

This paper identifies and focuses on a specific type of environmental development called discontinuity. Discontinuities in the forms of rapid technological innovations, regulatory reforms, institutional overhauls, and socio-cultural developments are the ...
Bhowmick, Bhaskar, Dixit, M. R.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Simultaneous localization and mapping in a multi-robot system in a dynamic environment with unknown initial correspondence. [PDF]

Front Robot AI, 2023
Malakouti-Khah H, Sadeghzadeh-Nokhodberiz N, Montazeri A.   +2 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

PSD-based intersection method for photoelectric detection of explosion position in field environments

AIP Advances
Accurate explosion localization is critical in defense research and civil blasting engineering, serving as a core technology in weapon development and controlled demolition.
Wenbo Chu, Pengfei Wang, Bin Zhang, Yuan Li, Donge Zhao   +4 more
doaj   +1 more source

Research on Road Surface Recognition Algorithm Based on Vehicle Vibration Data

Sensors
Road surface conditions significantly impact driving safety and maintenance costs. Especially in connected and automated vehicles (CAVs), the road surface type recognition is critical for environmental perception.
Jianfeng Cui, Hengxu Zhang, Xiao Wang, Yu Jing, Xiujian Chou   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source