Results 131 to 140 of about 3,584,282 (275)

Editorial: The embodied brain: computational mechanisms of integrated sensorimotor interactions with a dynamic environment, volume II. [PDF]

Front Comput Neurosci, 2023
Röhrbein F, Senden M.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

SLP-Improved DDPG Path-Planning Algorithm for Mobile Robot in Large-Scale Dynamic Environment. [PDF]

Sensors (Basel), 2023
Chen Y, Liang L.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Lightweight Multi-Head MambaOut with CosTaylorFormer for Hyperspectral Image Classification

Remote Sensing
Unmanned aerial vehicles (UAVs) equipped with hyperspectral hardware systems are widely used in urban planning and land classification. However, hyperspectral sensors generate large volumes of data that are rich in both spatial and spectral information ...
Yi Liu, Yanjun Zhang, Jianhong Zhang
doaj   +1 more source

Atypical action updating in a dynamic environment associated with adolescent obsessive-compulsive disorder. [PDF]

J Child Psychol Psychiatry, 2022
Marzuki AA, Vaghi MM, Conway-Morris A, Kaser M, Sule A, Apergis-Schoute A, Sahakian BJ, Robbins TW.   +7 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Challenges of Periodontal Tissue Engineering: Increasing Biomimicry through 3D Printing and Controlled Dynamic Environment. [PDF]

Nanomaterials (Basel), 2022
Roato I, Masante B, Putame G, Massai D, Mussano F.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Temperature field ultrafast detection and identification quantum sensor based on diamond array

Microsystems & Nanoengineering
Ultrafast temperature field detection and identification is crucial for applications ranging from environmental sensing and biomedical monitoring to thermal management in advanced energy systems.
Wei Gao, Jinyu Tai, Zhiqiang Xiang, Yunbo Shi, Xin Li, Huanfei Wen, Fei Deng, Zhonghao Li, Zongmin Ma, Hailong Wang, Weixuan Zhang, Zheng Lou, Hao Guo, Jun Tang, Lili Wang, Jun Liu   +15 more
doaj   +1 more source