Results 51 to 60 of about 75,918 (267)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Flow dynamics and haemostasis.
Annali dell'Istituto superiore di sanita, 2007 Fluid-dynamic conditions that are compatible with tensile stress on the bonds between platelet glycoprotein Ibalpha and immobilized Von Willebrand factor A1 domain (VWF-A1) led to Ca++ release from intracellular stores (type alpha/beta peaks), which preceded stationary platelet adhesion. Raised levels of cyclic adenosine monophosphate (cAMP) and cyclic
M. MAZZUCATO +4 more
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
ACCOUNTING INFLUENCE OF CENTRIFUGAL FORCE IN THE NUMERICAL MODELING OF RISING SWIRLED GAS FLOW
Известия высших учебных заведений: Нефть и газ, 2015 In work the consistent inclusion of centrifugal force in the numerical calculations of three-dimensional gas-dynamic characteristics of the unsteady flow of compressible viscous heat-conducting gas in an upward swirling flow caused by the vertical cold ...
S. P. Bautin, A. G. Obukhov
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Zhongguo dizhi zaihai yu fangzhi xuebaoHigh-altitude and long-runout geohazards encompass a range of surface processes involving single or cascading geological processes such as rockfalls, landslides, debris flows, and mudflows.
Yang GAO +3 more
doaj +1 more source
Dynamic Electroosmotic Flows of Power-Law Fluids in Rectangular Microchannels
Micromachines, 2017 Dynamic characteristics of electroosmosis of a typical non-Newtonian liquid in a rectangular microchannel are investigated by using numerical simulations.
Cunlu Zhao, Wenyao Zhang, Chun Yang
doaj +1 more source
Dynamics of Flow: A Nonlinear Perspective [PDF]
Journal of Happiness Studies, 2008 The aims of this study are to consider the experience of flow from a nonlinear dynamics perspective. The processes and temporal nature of intrinsic motivation and flow, would suggest that flow experiences fluctuate over time in a dynamical fashion. Thus it can be argued that the potential for chaos is strong.
Ceja, Lucía, Navarro Cid, José
openaire +2 more sources