Results 61 to 70 of about 990,723 (349)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

ACCOUNTING INFLUENCE OF CENTRIFUGAL FORCE IN THE NUMERICAL MODELING OF RISING SWIRLED GAS FLOW

open access: yesИзвестия высших учебных заведений: Нефть и газ, 2015
In work the consistent inclusion of centrifugal force in the numerical calculations of three-dimensional gas-dynamic characteristics of the unsteady flow of compressible viscous heat-conducting gas in an upward swirling flow caused by the vertical cold ...
S. P. Bautin, A. G. Obukhov
doaj   +1 more source

Selfish Routing on Dynamic Flows [PDF]

open access: yes, 2015
Selfish routing on dynamic flows over time is used to model scenarios that vary with time in which individual agents act in their best interest. In this paper we provide a survey of a particular dynamic model, the deterministic queuing model, and discuss
Antonsen, Christine
core   +2 more sources

Nonlinear parabolic flows with dynamic flux on the boundary

open access: yes, 2014
A nonlinear divergence parabolic equation with dynamic boundary conditions of Wentzell type is studied. The existence and uniqueness of a strong solution is obtained as the limit of a finite difference scheme, in the time dependent case and via a ...
Barbu, Viorel   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Vortex Dynamics of Oscillating Flows [PDF]

open access: yesArnold Mathematical Journal, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Vladimirov, V. A.   +2 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

A review of numerical simulation research on multi-phase dynamics of high-altitude and long-runout geohazards

open access: yesZhongguo dizhi zaihai yu fangzhi xuebao
High-altitude and long-runout geohazards encompass a range of surface processes involving single or cascading geological processes such as rockfalls, landslides, debris flows, and mudflows.
Yang GAO   +3 more
doaj   +1 more source

Dynamic Electroosmotic Flows of Power-Law Fluids in Rectangular Microchannels

open access: yesMicromachines, 2017
Dynamic characteristics of electroosmosis of a typical non-Newtonian liquid in a rectangular microchannel are investigated by using numerical simulations.
Cunlu Zhao, Wenyao Zhang, Chun Yang
doaj   +1 more source

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