Results 51 to 60 of about 848,441 (265)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Dynamic Analysis of Embankments Reinforced with Micro-Piles [PDF]
Analytical and Numerical Methods in Mining Engineering, 2019 Application of micro-piles to stabilize unstable slopes has been widely considered in recent years. A micro-pile is a small-diameter (typically less than 300 mm), drilled, and grouted as non-displacement pile that is typically reinforced.
پریسا طالبی +1 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Advances in Civil Engineering, 2018 In order to study the effect of cement-sand ratio on the dynamic mechanical properties of the full tailings cemented backfilling, three sets of full tailings cemented backfilling specimens with different cement-sand ratios were prefabricated.
Shan Yang +3 more
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Advances in Civil Engineering, 2022 Groundwater and earthquake are two of the factors behind the occurrence of slope instability. This paper focuses on the computation of the safety factor acting on a sandy slope when subjected to groundwater seepage and earthquake load.
Yulin Lu, Xiaoran Chen, Li Wang
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Dynamic increase factor for RC frame with specially shaped columns against progressive collapse [PDF]
Journal of Vibroengineering, 2017 To investigate the dynamic increase factor (DIF) for nonlinear static (NS) alternate path analysis, the nonlinear dynamic (ND) and static analysis of a 6-storey reinforced concrete (RC) frame with specially shaped columns are carried out by utilizing OpenSees after the corner, side or inner column is removed respectively.
Lei Zhang +3 more
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
BEHAVIOR FACTOR OF STEEL DUAL FRAMES WITH LARGE- SCALED CONCENTRICALLY BRACING SYSTEMS [PDF]
مجله مدل سازی در مهندسی, 2013 In this paper, the seismic behavior of steel dual frames with large-scaled concentrically bracings have been evaluated at special ductility level, and then the ductility reduction factor and the over-strength reduction factor for this type of structural ...
غلامرضا Abdollahzadeh +1 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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