Results 41 to 50 of about 34,001 (234)

Optimizing group utility in itinerary planning: a strategic and crowd-aware approach

Journal of Big Data
Itinerary recommendation is a complex sequence prediction problem with numerous practical applications. The task becomes significantly more challenging when optimizing multiple factors simultaneously, such as user queuing times, crowd levels, attraction ...
Junhua Liu, Aldy Gunawan, Kristin L. Wood, Kwan Hui Lim   +3 more
doaj   +1 more source

A Decomposition Algorithm to Solve the Multi-Hop Peer-to-Peer Ride-Matching Problem

, 2017
In this paper, we mathematically model the multi-hop Peer-to-Peer (P2P) ride-matching problem as a binary program. We formulate this problem as a many-to-many problem in which a rider can travel by transferring between multiple drivers, and a driver can ...
Jayakrishnan, R., Masoud, Neda
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

Biology Open, 2014
GLUT4 constitutively recycles between the plasma membrane and intracellular depots. Insulin shifts this dynamic equilibrium towards the plasma membrane by recruiting GLUT4 to the plasma membrane from insulin-responsive vesicles.
Kevin P. Foley, Amira Klip
doaj   +1 more source

For a social cartography of enconunters [PDF]

, 2017
This article results from the encounter and experience with the Social Cartography Methodology by Brazilian and Argentinean research groups, composed of architects, urban planners, and geographers in the Dunas neighborhood, within the periphery of ...
Diez Tetamanti, Juan Manuel, Mesquita Clasen, Carolina, Rocha, Eduardo   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A New Framework for Centralized Coordinated Multi-Vehicle Dynamic Routing

IEEE Access
In the context of rapid urbanization, the problem of long travel times has become a significant problem for contemporary cities, both socially and economically.
M. D. R. L. Silva, M. Tang
doaj   +1 more source