Results 141 to 150 of about 7,121,089 (359)

Loading device for oncoming dynamic loading

open access: yesTraktory i sel hozmashiny, 2014
Methods of running and testing of parts, units and aggregates under load in case of transferring required drive torques through them are considered. The method of loading by oncoming drive torques using inertial loaders is theoretically substantiated.
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

MOD-1 WTG dynamic analysis [PDF]

open access: yes
An analysis of the MOD-1 2000 kW horizontal axis wind turbine was given. The MOD-1 design was briefly described, and the analysis used to evaluate the dynamic loads and structural interactions is discussed. The resonant frequency placement, the treatment
Stahle, C. V., Jr.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Soft soils reinforced by rigid vertical inclusions [PDF]

open access: yesConstructii: Journal of Civil Engineering Research, 2013
Reinforcement of soft soils by rigid vertical inclusions is an increasingly used technique over the last few years. The system consists of rigid or semi-rigid vertical inclusions and a granular platform for the loads transfer from the structure to the ...
Iulia-Victoria NEAGOE
doaj  

Pressure responsive seal handles static and dynamic loads [PDF]

open access: yes, 1965
Ported ball valves are sealed under both static and dynamic load conditions by a line-pressure responsive double-acting seal. The top of the seal engages the ported ball at the outer circumferential edge of the seal upper end, and the bottom of the seal ...
Marsh, H. W.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Dynamics of early planetary gear trains [PDF]

open access: yes
A method to analyze the static and dynamic loads in a planetary gear train was developed. A variable-variable mesh stiffness (VVMS) model was used to simulate the external and internal spur gear mesh behavior, and an equivalent conventional gear train ...
August, R.   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Blade Sharpness and its Effect on the Testing of Body Armours [PDF]

open access: yes, 2002
Factors such as edge sharpness and tip sharpness have been identified by Horsfall,1 as keyvariables in the testing of stab and slash resistant armours.
Champion, Stephen M.   +3 more
core  

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