Results 151 to 160 of about 137,150 (318)

Lubricated contact analysis of a spur gear pair with dynamic loads [PDF]

open access: yes
In the present research study, a comprehensive spur gear lubrication analysis has been carried out to understand the gear contact behaviour under lubrication conditions.
Liu, Huaiju
core  

Modelling the vehicle in vehicle-infrastructure dynamic interaction studies

open access: yes, 2010
This paper presents the equations of motion for a general articulated road vehicle, with variable numbers of wheels for the tractor and trailer. The equations are applicable to vehicle-bridge dynamic interaction problems for two and three dimensional ...
O\u27Brien, Eugene J.   +3 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

基于行驶仿真试验的行星减速机动力学仿真

open access: yesJixie chuandong, 2006
The static strength theory applied in the design process of the planetary reducer can’t reflect the dynamic loads suffered by it,so the faults of the planetary reducer are more than the imagination in running process.In order to solve the problem ...
杜秀菊, 王兴贵
doaj  

Spur gear lubrication analysis with dynamic loads

open access: yes, 2013
A thermal elastohydrodynamic lubrication line contact model, which could handle ultra-thin-film conditions, was developed to study effects of speed on the lubrication performance of a spur gear pair.
Zhu, Caichao   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

THE RUBBER REINFORCED SUPPORT PARTS FOR COMPLEITING DYNAMICS AND QUIESCENT LOADS OF BRIDGE CONSTRUCTIONS

open access: yesNauka ta progres transportu, 2010
The research of deformation characteristics of the rubber reinforced support parts (RRBP), which compensate static and dynamic loadings of elements of bridge constructions, is conducted.
O. I. Skokov   +3 more
doaj  

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